Cervical Rippening With Antiprogesterone in Midtrimester Abortions
- Registration Number
- NCT00410345
- Lead Sponsor
- Hadassah Medical Organization
- Brief Summary
Induction of midtrimester abortion includes cervical ripening and then contraction to induce uterine evacuation. There are several protocols, but most of them include using prostaglandins (PG). The disadvantages of using PG include uncomfortable side effects and limits of using it for women after cesarean section. Mifepristone is an antiprogesterone drug and been used for induction of abortion in first and second trimesters abortions. The aim of this study is to explore the effectiveness of Mifepristone for cervical ripening before high dose Oxytocin drip.
- Detailed Description
The aim of this study is to explore the effectiveness of Mifepristone for cervical ripening before high dose Oxytocin drip in midtrimester abortions. After informed consent, all the women will be randomized for Mifepristone or placebo. 48 hours later, high dose oxytocin drip will be started and we will examine the success rate to induce abortion, the duration from starting oxytocin till evacuation of uterus and side effects.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 145
- midtrimester late abortion
- midtrimester induced abortion
- placenta previa
- infected abortion
- rupture of membranes
- s/p cesarean section *2 or more
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Pitocin Mifepristone Treatment with Pitocin after mifegine Cytotec Mifepristone Treatment with cytotec after mifegine
- Primary Outcome Measures
Name Time Method success of abortion induction abortion induction duration
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hadassah Medical Organization
🇮🇱Jerusalem, Israel