Construction and Application of Precise Diagnosis and Treatment System for Thyroid-associated Ophthalmopathy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- eye morphological parameters
研究概览
简要总结
This study aims to develop the deep learning-based system that integrates multimodal information to automatically diagnose, stage, and grade thyroid-associated ophthalmopathy (TAO), assist in treatment decision-making, and predict patient prognosis, thereby providing novel tools to support clinical management.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 7 Years 至 90 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •normal participants without eyelid disorders (control group)
- •patients with thyroid-associated ophthalmopathy (TAO group)
- •cooperative participants
排除标准
- •participants with pupil or cornea disorders
- •participants with history of eye injury
结局指标
主要结局
eye morphological parameters
时间窗: through study completion, average of 5 years
Margin reflex distances(mm)
Blinking feature of patients with thyroid-associated ophthalmopathy
时间窗: through study completion, average of 5 years
Blinking frequency
Ocular movement measurement
时间窗: through study completion, average of 5 years
Ocular movement ability in nine gaze positions
Automatic orbital structures segmentation and measurement using deep learning methods
时间窗: through study completion, average of 5 years
Automatic segmentation and measurement of orbital structures,such as eyeball, extraocular muscle, orbital fat, bony orbital region, optic nerves, etc
Automatic diagnosis, grading, staging and prediction of patients with thyroid-associated ophthalmopathy
时间窗: through study completion, average of 5 years
Patients with thyroid-associated ophthalmopathy(TAO) are classified as TAO or non-TAO. Grading is classified as mild, moderate, severe and sight-threatening. Staging is classified as active and stable.
three-dimensional eye parameters
时间窗: through study completion, average of 5 years
eyelid volume
次要结局
未报告次要终点