The Effects of High-Intensity Exercise on Biological Age
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Exercise
- Sponsor
- Loma Linda University
- Enrollment
- 35
- Locations
- 1
- Primary Endpoint
- venipuncture procedure
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The purpose of this graduate student research study is to determine if a high-intensity exercise program can slow or reverse biological (transcriptomic) aging and shed light on the underlying transcriptomic pathways involved.
Detailed Description
24 males and 24 females will be randomly assigned to either the control group or the exercise group. Baseline measures will be obtained, including questionnaires (on stress, sleep, depression, activity level, and fitness), body composition measures, vital signs, and a blood draw. Control group participants will make no modifications to regular diet or exercise habits for 30 days. Exercise group participants will perform supervised high intensity exercise three times per week at the LLU department of physical therapy laboratory utilizing treadmills, stationary bicycles, and rowing machines. Results will be collected following conclusion of the 30-day study protocol.
Investigators
Gurinder Bains
Associate Professor School of Allied Health
Loma Linda University
Eligibility Criteria
Inclusion Criteria
- •Sex: Both Males and Females
- •Age: 40-65 years old
- •Physical Fitness: Below average scores on the Self report fitness questionnaire
- •Physical Activity: Low as measured by the International Physical Activity Questionnaire
Exclusion Criteria
- •Prior (within the last 5 years) or current history of cardiovascular disease, stroke, unexplained weight loss, clinical depression, congestive heart failure, cancer, arrythmia, respiratory disease, or other serious medical conditions that would make exercise unsafe or prevent full participation in the exercise protocol.
- •Any self-reported significant increase or decrease in activity levels within the past thirty days.
- •Current use of the following medications: antibiotics, glucocorticoids, anticoagulants, narcotics, antiepileptic medications, antipsychotics, antidepressants, and hypoglycemic agents.
- •Current self-reported pregnancy
Outcomes
Primary Outcomes
venipuncture procedure
Time Frame: Change between baseline and 30 days
Participants will have 8ml of blood drawn on two separate occasions by a certified phlebotomist. The first 8 ml (1.62tsp) blood draw will occur at 8am on day 1 of the study protocol. The second 8ml (1.62tsp) blood draw will occur approximately 30 days later. The total blood draw volume will be 16ml or approximately 3.25 teaspoons. The blood draw is to test for the effects of exercise on gene expression and aging.
Secondary Outcomes
- Perceived stress scale survey(Change between baseline and 30 days)
- Pittsburgh Sleep Quality Index(Change between baseline and 30 days)