Molecular Genetics Studies of Cancer Patients and Their Relatives
- Conditions
- Malignant Neoplasm
- Interventions
- Other: Biospecimen CollectionOther: Questionnaire Administration
- Registration Number
- NCT04185935
- Lead Sponsor
- City of Hope Medical Center
- Brief Summary
This trial studies the genetic and behavioral factors that may contribute to the development of specific cancers and how these factors may affect the outcome of the disease in patients with a history of cancer and their relatives.
- Detailed Description
PRIMARY OBJECTIVES:
I. To identify rare cancer patients and families in whom the pattern of disease suggests a genetic susceptibility to cancer or other etiology suggestive of a carcinogenic exposure and to characterize the underlying predisposition.
II. To determine the contribution of heredity (genotype) and biomarkers to clinical outcome (phenotype, occurrence of new cancers, prognosis and quality of life) in subgroups of cancer patients with and without clinical high-risk features.
OUTLINE:
Patients may provide a sample of blood, a saliva sample, a sample of eyebrow plucks, a sample of urine, and/or stored tumor or healthy tissue.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 999999
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Individuals must have a personal history of cancer and/or a family history of cancer suggestive of the presence of an inherited predisposition. This inherited predisposition might manifest as:
- Young age cancer diagnosis
- Multiple primary neoplasms in affected member
- The presence of rare tumor types in the family
- Congenital malformations
- Any other family clustering of cancer
- Any other cancer-predisposing genetic diseases/conditions
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Individuals may also be eligible by participation in the City of Hope Cancer Screening & Prevention Program Network (CSPPN) clinical service or on the basis of membership in a group known or suspected to have an increased risk of carrying a genetic alteration or of sustaining a particular exposure that would place that at increased risk of cancer. (Examples would include members of occupational cohorts like asbestos workers, individuals with multiple dysplastic nevi in the absence of a family history of cancer, and individuals descended from a particular tribe in the American Southwest who have an increased incidence of a rare genetic alteration associated with an increased risk of a specific cancer.)
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Individuals and families may be referred to us in a number of different ways. After initial contact is made with a individual or family by family studies personnel; an individual within the bloodline will be identified as the historian. There may be more than one historian within a family
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At least one historian must be wiling to provide information or access as needed to contact appropriate family members for documentation of cancer and for consent. An individual is considered to be eligible to participate if they criteria; contact with relatives is not always indicated
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Individuals who are under 18 are eligible for study if they meet the criteria. Consent for participation must be given by a legal guardian or parent
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Deceased patients may be included in the study. Public records, such as death certificates, can be used to confirm information from individuals or family members. If medical records are needed, consent for these records will be obtained from the deceased's next of kin. Next of kin refers to the following hierarchy of relatives; spouse, offspring, parents, and siblings. (Any further use of next of kin in this protocol should relate back to this hierarchy.) Archived tissue samples, such as pathology blocks or snap frozen tumor from a pathology department tumor bank (discard specimens) may be used for genetic research
- A family may be ineligible for study if the historian will not allow access to anyone within the family and thus, the accuracy of the family history cannot be established
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Ancillary-correlative (biospecimen collection) Biospecimen Collection Participants may provide a sample of blood, a saliva sample, a sample of eyebrow plucks, a sample of urine, and/or stored tumor or healthy tissue. Ancillary-correlative (biospecimen collection) Questionnaire Administration Participants may provide a sample of blood, a saliva sample, a sample of eyebrow plucks, a sample of urine, and/or stored tumor or healthy tissue.
- Primary Outcome Measures
Name Time Method Cancer risk assessment Up to 10 years Exploratory biomarkers for future studies Up to 10 years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (42)
John Muir Medical Center-Concord Campus
🇺🇸Concord, California, United States
Aultman Health Foundation
🇺🇸Canton, Ohio, United States
USC / Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
Cancer Center of Santa Barbara
🇺🇸Santa Barbara, California, United States
Lynn Regional Cancer Center - West
🇺🇸Boca Raton, Florida, United States
Holy Cross Hospital
🇺🇸Fort Lauderdale, Florida, United States
Rush University Medical Center
🇺🇸Chicago, Illinois, United States
Kootenai Cancer Center
🇺🇸Post Falls, Idaho, United States
John H Stroger Jr Hospital of Cook County
🇺🇸Chicago, Illinois, United States
ProHealth Waukesha Memorial Hospital
🇺🇸Waukesha, Wisconsin, United States
Paoli Memorial Hospital
🇺🇸Paoli, Pennsylvania, United States
Saint Joseph Hospital - Orange
🇺🇸Orange, California, United States
Sutter Cancer Centers Radiation Oncology Services-Roseville
🇺🇸Roseville, California, United States
Instituto de Cancerologia Las Americas
🇨🇴Medellín, Colombia
Saint Jude Medical Center
🇺🇸Fullerton, California, United States
Frederick Oncology Hematology Associates
🇺🇸Frederick, Maryland, United States
Saint Charles Health System
🇺🇸Bend, Oregon, United States
Presbyterian Kaseman Hospital
🇺🇸Albuquerque, New Mexico, United States
Mount Kisco Medical Group at Northern Westchester Hospital
🇺🇸Mount Kisco, New York, United States
Hunterdon Medical Center
🇺🇸Flemington, New Jersey, United States
Steward Saint Elizabeth's Medical Center
🇺🇸Brighton, Massachusetts, United States
Saddleback Memorial Medical Center
🇺🇸Laguna Hills, California, United States
City of Hope Medical Center
🇺🇸Duarte, California, United States
Mercy Hospital
🇺🇸Cedar Rapids, Iowa, United States
Clinica del Country
🇨🇴Bogotá, Cundinamarca, Colombia
Salvador Zubiran National Institute of Health Sciences and Nutrition
🇲🇽Mexico City, Tlalpan, Mexico
University of Puerto Rico
🇵🇷San Juan, Puerto Rico
Reading Hospital
🇺🇸West Reading, Pennsylvania, United States
The Don and Sybil Harrington Cancer Center
🇺🇸Amarillo, Texas, United States
University of Guadalajara
🇲🇽Guadalajara, Jalisco, Mexico
Health Quest Medical Practice PC-Cardio Thoracic
🇺🇸Poughkeepsie, New York, United States
Monterrey Institute of Technology-TecSalud
🇲🇽Nuevo Leon, Mexico
Instituto Nacional de Enfermedades Neoplasicas
🇵🇪Lima, Peru
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
🇺🇸Houston, Texas, United States
Doctor's Hospital of Laredo
🇺🇸Laredo, Texas, United States
Valleywise Comprehensive Health Center - Phoenix
🇺🇸Phoenix, Arizona, United States
Suburban Hospital
🇺🇸Bethesda, Maryland, United States
New Mexico Oncology Hematology Consultants
🇺🇸Albuquerque, New Mexico, United States
Lovelace Medical Center-Downtown
🇺🇸Albuquerque, New Mexico, United States
Covenant Medical Center
🇺🇸Lubbock, Texas, United States
Saint Agnes Hospital/Agnesian Cancer Center
🇺🇸Fond Du Lac, Wisconsin, United States
Cheyenne Regional Medical Center-West
🇺🇸Cheyenne, Wyoming, United States