Molecular Genetics Studies of Cancer Patients and Their Relatives
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Malignant Neoplasm
- Sponsor
- City of Hope Medical Center
- Enrollment
- 999999
- Locations
- 42
- Primary Endpoint
- Exploratory biomarkers for future studies
- Status
- Recruiting
- Last Updated
- 10 months ago
Overview
Brief Summary
This trial studies the genetic and behavioral factors that may contribute to the development of specific cancers and how these factors may affect the outcome of the disease in patients with a history of cancer and their relatives.
Detailed Description
PRIMARY OBJECTIVES: I. To identify rare cancer patients and families in whom the pattern of disease suggests a genetic susceptibility to cancer or other etiology suggestive of a carcinogenic exposure and to characterize the underlying predisposition. II. To determine the contribution of heredity (genotype) and biomarkers to clinical outcome (phenotype, occurrence of new cancers, prognosis and quality of life) in subgroups of cancer patients with and without clinical high-risk features. OUTLINE: Patients may provide a sample of blood, a saliva sample, a sample of eyebrow plucks, a sample of urine, and/or stored tumor or healthy tissue.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Individuals must have a personal history of cancer and/or a family history of cancer suggestive of the presence of an inherited predisposition. This inherited predisposition might manifest as:
- •Young age cancer diagnosis
- •Multiple primary neoplasms in affected member
- •The presence of rare tumor types in the family
- •Congenital malformations
- •Any other family clustering of cancer
- •Any other cancer-predisposing genetic diseases/conditions
- •Individuals may also be eligible by participation in the City of Hope Cancer Screening \& Prevention Program Network (CSPPN) clinical service or on the basis of membership in a group known or suspected to have an increased risk of carrying a genetic alteration or of sustaining a particular exposure that would place that at increased risk of cancer. (Examples would include members of occupational cohorts like asbestos workers, individuals with multiple dysplastic nevi in the absence of a family history of cancer, and individuals descended from a particular tribe in the American Southwest who have an increased incidence of a rare genetic alteration associated with an increased risk of a specific cancer.)
- •Individuals and families may be referred to us in a number of different ways. After initial contact is made with a individual or family by family studies personnel; an individual within the bloodline will be identified as the historian. There may be more than one historian within a family
- •At least one historian must be wiling to provide information or access as needed to contact appropriate family members for documentation of cancer and for consent. An individual is considered to be eligible to participate if they criteria; contact with relatives is not always indicated
Exclusion Criteria
- •A family may be ineligible for study if the historian will not allow access to anyone within the family and thus, the accuracy of the family history cannot be established
Outcomes
Primary Outcomes
Exploratory biomarkers for future studies
Time Frame: Up to 10 years
Cancer risk assessment
Time Frame: Up to 10 years