Concomitant Epicardial Pulmonary Vein Isolation in Patients With Atrial Fibrillation Undergoing Elective Cardiac Surgery
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Atrial Fibrillation
- Sponsor
- Medisch Spectrum Twente
- Enrollment
- 2
- Locations
- 1
- Primary Endpoint
- Recurrence of atrial fibrillation
- Status
- Terminated
- Last Updated
- 9 years ago
Overview
Brief Summary
Recent studies demonstrated that radiofrequency isolation of the pulmonary veins (PVI) is a superior alternative to antiarrhythmic drug therapy in patients with symptomatical paroxysmal atrial fibrillation (AF). A substantial proportion of patients undergoing elective cardiac surgery also suffer from atrial fibrillation. No evidence exists if epicardial PVI is beneficial in patients with a history of AF undergoing coronary bypass surgery (CABG) for the concomitant treatment of AF. The investigators aim to establish the effectiveness of incorporating epicardial pulmonary vein isolation into elective cardiac surgery.
Investigators
B. Oude Velthuis
B. Oude Velthuis MD.
Medisch Spectrum Twente
Eligibility Criteria
Inclusion Criteria
- •Patients ≥ 18 years of age
- •EHRA class ≤ 2
- •Documented history of paroxysmal, persistent, longstanding persistent or newly-diagnosed AF prior to admittance for cardiac surgery
- •Patients will have elective coronary surgery planned Able of providing informed consent
Exclusion Criteria
- •Patients ≥70 years of age
- •Pregnancy Patients with contraindications for oral anticoagulant agents
- •Patients undergoing emergency operation
- •Patients undergoing concomitant valve replacement
- •Severely enlarged LA (\>50 mm) on echocardiography
- •Prior AF ablation or AF surgery
Outcomes
Primary Outcomes
Recurrence of atrial fibrillation
Time Frame: one year
The percentage of patients without a recurrence of AF, without antiarrhythmic drugs (AADs), within a follow-up period of at least 12 months after a stabilisation period of 90 days after the initial procedure. An episode of AF is defined as an episode of at least 30 seconds duration.
Secondary Outcomes
- Duration of hospitalization(One year)