Environmental Exposure and Neurological Diseases Questionnaire

Completed

• Conditions: Amyotrophic Lateral Sclerosis
• Interventions: Other: Patient Registry

• Registration Number: NCT02916966
• Lead Sponsor: Dartmouth-Hitchcock Medical Center

Brief Summary

The proposed research is particularly relevant to the National ALS Registry and public environmental health issues because it addresses the potential environmental causes of sporadic ALS. The research will develop an ALS surveillance program in Ohio that can be compared with the national and State-Metro Surveillance Programs of the National ALS Registry, and novel methodologies to determine the role of the cyanobacterial toxin, BMAA (beta-methylamino-L-alanine), and other environmental toxins/toxicants as risk factors for ALS. This work will advance the mission of the Centers for Disease Control Agency for Toxic Substances and Disease Registry (CDC ATSDR) National ALS Registry by offering data on ALS cases in Ohio that address public health concerns over the effects of chronic exposure to cyanobacterial blooms in Lake Erie.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2016-09-26
• Study First Submitted QC: 2016-09-27
• Study First Posted: 2016-09-28
• Study Start: 2016-10
• Primary Completion: 2023-09
• Study Completion: 2023-09
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-30
• Last Update Posted: 2024-05-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 460

Inclusion Criteria

• ALS
• Non-neurodegenerative controls
• Can willingly give consent
• Over 18 years of age

Exclusion Criteria

• Cannot give consent
• Under 18 years of age

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ALS Patients in Case-Control	Patient Registry	ALS patients enrolled by Cleveland Clinic Foundation (CCF)
Non-neurodegenerative patients in case control	Patient Registry	Non-neurodegenerative patients enrolled by CCF
Non-neurodegeneration population in population control	Patient Registry	Non-neurodegenerative general population enrolled by ABS mailing system from DHMC
ALS Patients in State of OH	Patient Registry	ALS registry of all cases in Ohio

Primary Outcome Measures

Name	Time	Method
Questionnaire for Environmental Exposures, Toxins, and Neurological Disease	1 year

Trial Locations

Locations (1)

Cleveland Clinic Foundation; 🇺🇸 Cleveland, Ohio, United States