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临床试验/NCT02621372
NCT02621372Unknown不适用

Correlation of Platelets Count With Endoscopic Findings in a Cohort of Egyptian Patients With Liver Cirrhosis

Sherief Abd-Elsalam1 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2015年1月最近更新:
适应症

试验速览

阶段
不适用
发起方
入组人数
100
试验地点
1
主要终点
Number of patients with esophageal varices and have low platelet count

研究概览

简要总结

Portal hypertension is a common complication of liver cirrhosis that can lead to development of esophageal varices (EV). They are abnormally dilated veins within the wall of the esophagus that lead to haemorrhage (1). Majority of patients with cirrhosis will develop EV at some point, and about third of these patients will have at least one bleeding episode because of rupture of a varix . For this reason, screening endoscopy for detection of the presence of EV should be part of the diagnostic work-up in patients with cirrhosis. This is a very important preventive step for identification of those patients with variceal bleeding risk and furthermore, identification of patients in urgent need for prophylactic treatment.

All guidelines stress on screening endoscopy for early detection of EV in cirrhotic patients with portal hypertension. However this approach is limited by its invasiveness and cost effectiveness issues of screening endoscopy .

详细描述

Recent research has focused on the use of noninvasive methods to detect patients with the intention of avoiding endoscopy in low-risk cases . Thrombocytopenia (platelet count < 150,000/μl) is a common complication in patients of chronic liver disease (CLD) . So, the investigators in this research formulated this study to determine whether platelet count can predict the presence of EV or varices which need prophylactic therapy (medium or large size EV) in a cohort of Egyptian patients with liver cirrhosis and can identify patients with the intention of avoiding endoscopy in low-risk cases.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Other

入排标准

性别
All
接受健康志愿者

入选标准

  • Diagnosis of cirrhosis based on history, physical examination, laboratory tests, ultrasound scans and liver biopsy in some occasion.

排除标准

  • Hepatocellular carcinoma.
  • Portal vein thrombosis.
  • Parenteral drug addiction.

结局指标

主要结局

Number of patients with esophageal varices and have low platelet count

时间窗: 1 year

次要结局

未报告次要终点

研究者

发起方
Sherief Abd-Elsalam
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Sherief Abd-Elsalam

Hepatology and gastroenterology dept., tanta university, M.D., Principle investigator

Tanta University

研究点 (1)

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