Cardiopulmonary Exercise Testing in Cardiosurgery Patients

Recruiting

• Conditions: Postoperative Complications

• Registration Number: NCT06702059
• Lead Sponsor: St. Anne's University Hospital Brno, Czech Republic

Brief Summary

Cardiopulmonary exercise testing (CPET) is considered to be a gold standard in pre-operative risk assessment and stratification of high risk patients scheduled for major surgery. Surprisingly, only a limited number of studies examined the prognostic role of CPET in cardiothoracic surgery. This is in contrast with rather poor discriminating quality of cardiovascular surgery risk scores and predominantly elderly cardiovascular surgery patients, with significant comorbidity and high degree of frailty. Recently, CPET was shown feasible in coronary artery bypass grafting surgery candidates. Additionally, the rest parameter, which is the partial pressure of end-tidal carbon dioxide (PETCO2) and a submaximal exercise parameter (the VE/VCO2 slope) with good prognostic utility across multiple respiratory exchange ratio values), has been shown to predict mortality and post-operative complications.

Whether these rest and submaximal exercise parameters can be used to predict postoperative complications in cardiovascular surgery patients is yet to be determined.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-11-20
• Study First Submitted QC: 2024-11-20
• Study First Posted: 2024-11-22
• Study Start: 2024-12-01
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-12
• Last Update Posted: 2025-05-15
• Primary Completion: 2027-12-31
• Study Completion: 2028-04-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 130

Inclusion Criteria

• patients scheduled for coronary artery bypass graft surgery

Exclusion Criteria

• not able to perform cardiopulmonary exercise testing, off-pump revascularization, without full sternotomy, previous cardiac surgery

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
post-operative pulmonary complications	within 30 post-operative days	pneumonia, atelectasis, respiratory failure, ARDS
post-operative cardiovascular complications	within 30 post-operative days	new arrhythmias (atrial fibrillation, supraventricular tachycardia, etc.), myocardial infarction/minimal myocardial lesion, hypotension, heart failure, pulmonary edema, pulmonary embolism, cardiopulmonary resuscitation

Secondary Outcome Measures

Name	Time	Method
Hospital and Intensive care length of stay	within 30 post-operative days	Hospital and Intensive care length of stay

Trial Locations

Locations (2)

Centre of Cardiovascular and Transplantation Surgery; 🇨🇿 Brno, Czech Republic, Czechia

St. Anne's University Hospital in Brno; 🇨🇿 Brno, Czech Republic, Czechia