Comparison of the effects of dexmedetomidine, lignocaine and ketamine pretreatment on propofol injection pain: a randomized clinical trial.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 156
- 试验地点
- 1
- 主要终点
- Intensity of pain during propofol injection
研究概览
简要总结
This randomized, double-blind, comparative clinical study aims to evaluate the effectiveness of three pharmacological agents-dexmedetomidine, ketamine and lignocaine-reducing pain associated with intravenous propofol injection during anaesthesia induction. A total of 156 patients (ASA physical status I and II), schedule for elective surgeries under general anaesthesia, will be enrolled and randomly assigned to one of three groups. Group D will receive 0.25mcg/kg dexmedetomidine, Group K will receive 0.5mg/kg, and Group L will receive 0.5mg/kg lignocaine each diluted in 5ml of normal saline administered intravenously before propofol injection. Pain response will be evaluated using a standardized four point scale. The findings will help determine the most effective pretreatment strategy for minimizing propofol injection pain.
研究设计
- 研究类型
- Interventional
- 分配方式
- Permuted block randomization, fixed
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients of age group 18 to 60 years.
- •Patients of ASA-PS grade I or II.
排除标准
- •Patients with history of allergy to propofol and the study drugs.
- •Patients with anticipated difficult venous access.
- •Patients with neurological deficits or psychiatric disorders.
- •Patients with history of drug abuse (alcohol, sedative, and analgesic).
- •Patients with cardiac disease (hemodynamically unstable, ischaemic heart disease), hepatic, renal, pulmonary disease and seizures Patients with morbid obesity.
- •Patients with pregnancy and breastfeeding.
- •Patients with acute or chronic pain syndromes.
- •Patients with disorders of lipid metabolism.
- •Patients with thrombophlebitis.
结局指标
主要结局
Intensity of pain during propofol injection
时间窗: Intensity of pain during propofol injection, assessed using a verbal response scale within 30 seconds of propofol administration.
次要结局
- Heamodynamic changes (hypotension, bradycardia, hypertension, tachycardia) after propofol administration.(Heamodynamic changes (hypotension, bradycardia, hypertension, tachycardia) baseline before, during and 1, 3 minutes after propofol administration.)