A study to compare the effect of dexmedetomidine, lignocaine, and ketamine in reducing pain during propofol injection in adult patients.

Not yet recruiting

Brief Summary: This randomized, double-blind, comparative clinical study aims to evaluate the effectiveness of three pharmacological agents-dexmedetomidine, ketamine and lignocaine-reducing pain associated with intravenous propofol injection during anaesthesia induction. A total of 156 patients (ASA physical status I and II), schedule for elective surgeries under general anaesthesia, will be enrolled and randomly assigned to one of three groups. Group D will receive 0.25mcg/kg dexmedetomidine, Group K will receive 0.5mg/kg, and Group L will receive 0.5mg/kg lignocaine each diluted in 5ml of normal saline administered intravenously before propofol injection. Pain response will be evaluated using a standardized four point scale. The findings will help determine the most effective pretreatment strategy for minimizing propofol injection pain.

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

Patients with history of allergy to propofol and the study drugs.
Patients with anticipated difficult venous access.
Patients with neurological deficits or psychiatric disorders.
Patients with history of drug abuse (alcohol, sedative, and analgesic).
Patients with cardiac disease (hemodynamically unstable, ischaemic heart disease), hepatic, renal, pulmonary disease and seizures Patients with morbid obesity.
Patients with pregnancy and breastfeeding.
Patients with acute or chronic pain syndromes.
Patients with disorders of lipid metabolism.
Patients with thrombophlebitis.

Primary Outcome Measures

Name	Time	Method
Intensity of pain during propofol injection	Intensity of pain during propofol injection, assessed using a verbal response scale within 30 seconds of propofol administration.

Secondary Outcome Measures

Name	Time	Method
Heamodynamic changes (hypotension, bradycardia, hypertension, tachycardia) after propofol administration.	Heamodynamic changes (hypotension, bradycardia, hypertension, tachycardia) baseline before, during and 1, 3 minutes after propofol administration.

Locations (1): Regional Institute of Medical Sciences
🇮🇳
West, MANIPUR, India
Regional Institute of Medical Sciences
🇮🇳West, MANIPUR, India
Dr James Lego
Principal investigator
9402829222
jameslegodr@yahoo.com