Gingival Crevicular Fluid And Salivary Levels of Galectin-3 in Patients With Gingivitis And Patients With Stage III Periodontitis: An Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- galectin-3 in GCF
研究概览
简要总结
The aim of this study is to assess the levels of galectin-3 in the GCF and saliva in patient with gingivitis and patient with stage III periodontitis.
详细描述
The aim of this study is to assess the levels of galectin-3 in the GCF and saliva in patient with gingivitis and patient with stage III periodontitis.
This study will be conducted in the Oral Medicine and Periodontology department, Faculty of Dentistry- Cairo University, Egypt.
Patients will be selected from the outpatient clinic of the department of Oral Medicine and Periodontology, Faculty of Dentistry-Cairo University.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For healthy group: individuals with less than 10% bleeding on probing area, having a probing depth less than 4mm and no loss of attachment were included in the study.
- •For the gingivitis group: individuals with 10% or more bleeding on probing area, having a probing depth of less than 4mm and no attachment loss.
- •For the periodontitis group that has not received periodontal treatment in the last 6 months
- •For the periodontitis group: individuals with 30% or more bleeding on probing area, at least 2 teeth not adjacent to each quarter jaw with a depth of 5 mm or more and 4 mm or more attachment loss, coronal 1/3 and more on radiography (horizontal and / or vertical) bone loss.
- •Presence of a minimum of 15 natural teeth.
排除标准
- •Individuals with any known systemic disease.
- •Pregnant and lactating women.
- •Individuals that received periodontal treatment within the last 6 months.
- •Individuals with a history of systemic antibiotics and anti-inflammatory drugs within the last 3 months.
- •Former or current smokers.
结局指标
主要结局
galectin-3 in GCF
时间窗: 24 hours after taking the clinical measurements at the first visit
The total amount of Galectin-3 in GCF
galectin-3 in saliva.
时间窗: 24 hours after taking the clinical measurements at the first visit
The total amount of Galectin-3 in saliva
次要结局
- Plaque Index(24 hours before taking GCF and salivary samples)
- Pocket depth(24 hours before taking GCF and salivary samples)
- Clinical attachment level(24 hours before taking GCF and salivary samples)
- Bleeding on Probing(24 hours before taking GCF and salivary samples)
研究者
Mohamed saad arafa ali
Principal Investigator mohamed saad
Cairo University