A physiological study of the metabolism of fumarate in cancer using hyperpolarised 13C magnetic resonance imaging

Cambridge University Hospitals NHS Foundation Trust0 个研究点目标入组 90 人开始时间: 2023年10月5日最近更新: 2024年8月5日

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•All participants:
•1. Over 18 years old
•2. Able to and provide written informed consent to participate
•3. If female, postmenopausal or if women of childbearing potential (WOCBP) using a suitable contraception
•4. If male, using a suitable contraceptive method for the duration of the study
•Healthy volunteers (Stage 1):
•Not on any regular medications (except the oral contraceptive pill) that may impact the study results as determined by the researcher
•Cancer patients (Stage 2):
•1. Radiologically evaluable disease as established by clinical imaging
•2. Capable of undergoing repeat study visits

•The presence of any of the following will preclude participation as determined by the delegated investigator:
•1. Contraindication or inability to tolerate MRI
•2. Pregnant or actively breast-feeding woman
•3. If using an intrauterine contraceptive device (IUCD) as a method of contraception the device should be MRI-safe at 3 T (researcher to confirm)
•4. Clinically significant cardiac, pulmonary or neurological diseases as determined by the investigators
•5. Laboratory abnormalities that may impact the study results
•6. Any other significant medical or psychiatric history rendering the subject ineligible as deemed by the investigators

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