Moderate Intensity Intermittent Walking Training (MIWT) Improves Thyroid Function and Cardiometabolic Risk Factors in Obese Postmenopausal Women
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 36
- Locations
- 1
- Primary Endpoint
- Thyroid hormones
Study Overview
Brief Summary
The goal of this clinical trial is to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. The main question it aims to answer is:
Does MIWT enhance thyroid function and reduce cardiometabolic risk factors in this population? Researchers will compare MIWT (designed to MIWT group) to non-training intervention (designed to control group) to see if the training program works to improve thyroid function and cardiometabolic risk factors.
Participants in MIWT group will: perform a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions).
Participants in control group will : not perform any physical training and maintain their usual daily activities.
Detailed Description
This study aimed to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. Thirty-six obese postmenopausal women (BMI≥30 kg.m-2, aged 50-60 yrs.) were randomized to either a moderate-intensity intermittent walking training (MIWT) group (n=18) or control group (CG, n=18). Participants performed a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Body composition, thyroid hormones (thyroid stimulating hormone (TSH) and thyroxine free (FT4)), lipid profile (triglycerides (TRG), total cholesterol(TC), high-density lipoprotein cholesterol(HDLC) and low-density lipoprotein cholesterol(LDLC)), blood pressure (systolic and diastolic blood pressure) and aerobic fitness (6MWT) were determined before and after the MIWT.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Health Services Research
- Masking
- None
Eligibility Criteria
- Ages
- 50 Years to 60 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Body mass index≥ 30 kg.m-
- •Age between 50 and
- •Amenorrhea for >12 months.
- •Stable eating habits.
Exclusion Criteria
- •Chronic diseases.
- •Medical contraindications to physical activity.
- •Hormone replacement therapy.
Arms & Interventions
MIWT group
The MIWT group received moderate intensity intermittent walking training four times per week for 10 weeks.
Intervention: Moderate intensity intermittent walking training (Other)
Control group
The control group received no intervention for 10 weeks.
Outcomes
Primary Outcomes
Thyroid hormones
Time Frame: At baseline and after ten weeks of MIWT.
Serum thyroid hormone concentrations are measured from a blood sample (5 ml) obtained from a prominent superficial vein in the antecubital region.
Lipid profile
Time Frame: At baseline and after ten weeks of MIWT.
Measured by blood samples (5ml) from a prominent superficial vein in the antecubital region.
Body composition
Time Frame: At baseline and after ten weeks of MIWT.
Body composition was assessed using an electronic scale (Tanita BC-533, Tokyo, Japan),
Secondary Outcomes
- Heart rate(At baseline and after ten weeks of MIWT)
- 6 min walking test distance(At baseline and after ten weeks of MIWT)
- Perceived exertion rating(At baseline and after ten weeks of MIWT.)
- Systolic and diastolic blood pressure(At baseline and after ten weeks of MIWT.)
Investigators
Wissal Abassi
Principal Investigator
High Institute of Sports and Physical Education of Kef