Periodontal Pathogens and Atherom Plaque The Number of Mitochondrial DNA Copies
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 51
- 试验地点
- 1
- 主要终点
- Bacterial frequency (%)
研究概览
简要总结
Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream.
详细描述
Periodontitis is a chronic inflammatory disease of the tooth-supporting tissues characterized by the constant interaction of microorganisms in subgingival plaque and host defense mechanisms. Periodontitis is considered a focus of infection caused by oral bacteria, bacterial byproducts, or inflammatory mediators that can interact with other parts of the body via the bloodstream.
Periodontal bacteria produce endotoxins in the form of lipopolysaccharide (LPS). Circulating LPS reacts with Toll-like receptors, promoting the production of reactive oxygen species and phagocytosis in the intima layer. Oxidative stress has been reported to be associated with mtDNA copy number.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 25 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosed with endarterectomy
- •Not receiving chemotherapy
- •Not having received this treatment before
排除标准
- •Having systemic infection
- •Patients with severe heart disease
研究组 & 干预措施
Patients diagnosed with endarterectomy
干预措施: atheroma plaque (Other)
Patients diagnosed with endarterectomy
干预措施: Dental plaque (Other)
结局指标
主要结局
Bacterial frequency (%)
时间窗: Months 6-9 of the study
The percentage of bacteria in the red complex in atheroma plaque and dental plaque is evaluated using polymerase chain reaction methods.
次要结局
- Changes in mtDNA copy number (number)(Months 6-9 of the study)
- periodontal healths (mm)(8 months)
研究者
Ayşe Toraman
associate professor
Istanbul Saglik Bilimleri University