True Ileal Digestibility of Different Plant-based Proteins in a Human Ileostomy Model
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 11
- 试验地点
- 2
- 主要终点
- True ileal digestibility of different plant-based proteins
研究概览
简要总结
The goal of this interventional study is to learn about the digestibility of different plant-based proteins in adults (age 18-75) with an ileostomy.
The main questions the study aims to answer are:
- How does the digestibility of proteins in the small intestine differ between different plant-based proteins?
- Which proteins and amino acids are not digested or absorbed in the small intestine and are available for further metabolic processes in the large intestine?
- How do metabolites in the collected content of the ileostomy bag differ after consuming different plant-based proteins?
- Can the in vivo results be compared to results from existing in vitro models?
Participants will consume five different protein meals (oat protein - high bioavailable, oat protein - low bioavailable, pea protein - high bioavailable, pea protein low bioavailable, protein-free meal) on five different study days in a random order. Five hours after consuming the test meals ileostomy bags will be collected and the content will be analysed to answer the above mentioned research questions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age: 18 - 75 years
- •Body mass index: 18.5 - 30 kg/m2
- •(double-loop) Ileostomy with an intact small bowel
- •Signed informed consent
排除标准
- •Pregnancy or breastfeeding
- •Ileostomy < 3 months before the study
- •Any clinically significant present or past disease/condition other than colon cancer which in the investigator's opinion could interfere with the results of the trial
- •Any clinically significant present or past medication which in the investigator's opinion could interfere with the results of the trial
研究组 & 干预措施
Dietary Intervention Sequence 1 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 1 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 1 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 1 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 1 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Protein-free meal (Dietary Supplement)
Dietary Intervention Sequence 2 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 2 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 2 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 2 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 2 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Protein-free meal (Dietary Supplement)
Dietary Intervention Sequence 3 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 3 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 3 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 3 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 3 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Protein-free meal (Dietary Supplement)
Dietary Intervention Sequence 4 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 4 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 4 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 4 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 4 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Protein-free meal (Dietary Supplement)
Dietary Intervention Sequence 5 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 5 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 5 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 5 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 5 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Protein-free meal (Dietary Supplement)
Dietary Intervention Sequence 6 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 6 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 6 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 6 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 6 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Protein-free meal (Dietary Supplement)
Dietary Intervention Sequence 7 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 7 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 7 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 7 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 7 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Protein-free meal (Dietary Supplement)
Dietary Intervention Sequence 8 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 8 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 8 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 8 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 8 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Protein-free meal (Dietary Supplement)
Dietary Intervention Sequence 9 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 9 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 9 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 9 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 9 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Protein-free meal (Dietary Supplement)
Dietary Intervention Sequence 10 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 10 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 10 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 10 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 10 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Protein-free meal (Dietary Supplement)
Dietary Intervention Sequence 11 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 11 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Oat Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 11 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, low bioavailability (Dietary Supplement)
Dietary Intervention Sequence 11 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Pea Protein, high bioavailability (Dietary Supplement)
Dietary Intervention Sequence 11 (Meals: Pea protein (2x), Oat protein (2x), Protein-free (1x))
The participant will consume the below mentioned meals in a random order on five different study days (one on each visit):
- Protein meal: pea protein, low bioavailability
- Protein meal: pea protein, high bioavailability
- Protein meal: oat protein, low bioavailability
- Protein meal: oat protein, high bioavailability
- Protein-free meal
干预措施: Protein-free meal (Dietary Supplement)
结局指标
主要结局
True ileal digestibility of different plant-based proteins
时间窗: 0-5 hours after consumption of test meal (on all 5 study days)
The primary outcome is defined as the differences in the true ileal digestibility, determined by measuring the amount of nitrogen in the meal and the amount of unabsorbed nitrogen in the ileal fluid after consuming four different plant-based protein meals
次要结局
- Differences between in vivo and in vitro data(In vivo data: 0-5 hours after consumption of test meal (on all 5 study days))
- Protein and metabolite profiles in ileostomy digesta(0-5 hours after consumption of test meal (on all 5 study days))