The Intensive Care Infection Score to predict microbial infection and its sequelae in critically ill lung and heart transplant patients.
- Conditions
- bloodstream infectionSepsis10019815
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion Criteria
All patients above the age of 18 years who will undergo lung or heart transplantation are possibly eligible for this trial.
Exclusion Criteria
N.A.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The likelihood of microbial infection and its invasiveness (bloodstream<br /><br>infection). On the basis of the collected data the investigators, blinded to<br /><br>the study results, will decide after completion of the study whether a proven<br /><br>local infection or not was present from day 0-7 after inclusion. In case of<br /><br>disagreement a third party will be consulted. Source and likelihood of<br /><br>infection will be based on criteria defined at the International Sepsis Forum<br /><br>Consensus Conference.</p><br>
- Secondary Outcome Measures
Name Time Method <p>1.Septic shock. The SIRS criteria according to the ACCP/ SCCM consensus<br /><br>conference criteria of: a body temperature >38º C; a heart rate of >90 beats/<br /><br>min; a respiratory rate > 20 breaths/ min or mechanical ventilation or white<br /><br>cell count (WBC) of < 4.0 x 109/L, will be used. When SIRS and a probable/<br /><br>proven infection or BSI was present, patients will be classified as having<br /><br>sepsis. Shock will be defined by a systolic arterial pressure of < 90 mm Hg or<br /><br>mean arterial pressure (MAP) < 70 mm Hg for at least one hour despite adequate<br /><br>fluid resuscitation or requirement of vasopressor support to maintain MAP, from<br /><br>day 0 to 7.<br /><br>2. All cause mortality refers to day 28 (within ICU of hospital mortality after<br /><br>inclusion and ICU mortality).<br /><br>3. The effect of immunosuppressive medication on the intensive care infection<br /><br>score will be analyzed.</p><br>