Perioperative Goal Directed Fluid Therapy During Esophageal Resection A Prospective Randomized Controlled Open Multi-centre Trial to Study the Effect on Postoperative Complications
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Esophageal Cancer
- Sponsor
- University Hospital, Linkoeping
- Enrollment
- 64
- Locations
- 1
- Primary Endpoint
- Incidence of complications 5 and 30 days postoperatively
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Surgery for cancer of the esophagus is associated with a high risk of postoperative complications. It has been shown that the risk of postoperative complications can be decreased by optimising the amount and type of infusion fluids given during surgery, steered by measurement of cardiac stroke volume, mostly done with a device called esophageal Doppler. This device can however not be used during this type of surgery. This study wants to test the hypothesis that postoperative complications in patients operated for esophageal cancer can be partially prevented by using a goal directed strategy for the administration of fluids and drugs influencing the heart and vessels, based on measurement of stroke volume by pulse wave analysis (FloTrac).
Investigators
Lena Nilsson
MD pHd
University Hospital, Linkoeping
Eligibility Criteria
Inclusion Criteria
- •Patients scheduled for transthoracic esophageal resection because of malignancy, without colonic interposition who leave informed consent
Exclusion Criteria
- •ASA 4 or 5
- •Atrial Fibrillation
- •Significant Aortic or Mitral Valve Insufficiency
- •Preoperative planned extensive monitoring beyond CVP, arterial blood pressure, diuresis, ECG and other standard monitors
Outcomes
Primary Outcomes
Incidence of complications 5 and 30 days postoperatively
Time Frame: 5 and 30 days postoperatively
Secondary Outcomes
- length of stay ICU and total hospital(30 days)
- return of bowel function(30 days)