KCT0008003
Completed
未知
Clinical study to comparing the pain improvement effects and Safety of injection with Conjuran®(polynucleotide) and hyruan plus® in Patients with Knee Osteoarthritis: Double-blind, Randomized, Single-center, Active-controlled
Seoul Metropolitan Government Seoul National University Boramae Medical Center0 sites60 target enrollmentTBD
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Diseases of the musculoskeletal system and connective tissue
- Sponsor
- Seoul Metropolitan Government Seoul National University Boramae Medical Center
- Enrollment
- 60
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\)Adult over 40 years old
- •2\)Patient with knee osteoarthritis of grade I\-IV according to Kellgren\-Lawrence grading scale (K\-L grade)
- •3\)Patient who has more than one knee having a weight\-bearing pain of at least 40mm evaluated by 100mm VAS (the chosen indicator knee joint(targeted knee for this trial) can not change during this trial.)
- •4\)Patients expected to be willing to give a written consent and comply with procedures of this clinical trial
Exclusion Criteria
- •1\)Patient with previous traumatic history or trauma which could affect the results of this trial such as fracture of indicator knee joint(targeted knee for this trial)
- •2\)Patient with rheumatoid arthritis or other metabolic arthritis
- •3\)Patient with inflammation(ex: Osteomyelitis) at indicator knee joint(targeted knee joint for this trial) or around it
- •4\)Patient who have joint replacement surgery or procedures in the indicator knee joint(targeted knee joint for this trial)
- •5\)Patient who have hip joint osteoarthritis in ipsilateral side of the indicator knee joint(targeted knee joint for this trial)
- •6\)Patient with other diseases that may affect the safety and efficacy evaluation of the indicator knee joint (e.g., patients with severe pain, such as complex site pain syndrome, Paget's disease, intervertebral disc prolapse, and gout, recurrent pseudo\-gout)
- •7\)Patient who received intra\-articular hyaluronic acid injections within the previous 6 months of baseline (before study) or those who received intra\-joint steroid injections within 3 months or who received oral steroid within a month.
- •8\)Patient who needs to take or is taking anticoagulants or platelet aggregation which affect the blood coagulation
- •Injectable anticoagulants: low molecular weight and non\-fractional heparin injections, etc.
- •Oral anticoagulants: Warfarin, Dabigatran, Rivaroxaban, etc.
Outcomes
Primary Outcomes
Not specified
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