JPRN-UMIN000006423已完成未知
The clinical trial to assess efficacy of mexiletine for amyotrophic lateral sclerosis - Mexiletine on amyotrophic lateral sclerosis
Department of Neurology, Graduate School of Medicine, Chiba University, Japan.0 个研究点目标入组 60 人开始时间: 2011年10月1日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 60
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20years-old 至 ot applicable（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •1)Patient did not have ability to comprehend informed consent 2)Patient had uncompensated medical illness 3)Patient had cardiac disease (myocardial infarction, valvular disease and cardiomyopathy etc.) 4)Patient had arrhythmia (incomplet AV-block and bundle branch block etc.) 5)Significant sinus bradycardia 6)Hypotension 7)Hypokalemia 8)Patient already administered anti-arrhythmic drug 9)Woman is pregnant or is breast-feeding 10)Subjects had forced vital capacity of< 60% predicted 11)Subjects were not allowed to take any other experimental agents 3 months before. 12)Subjects had concomitant disease effects peripheral nerve (diabetic peripheral neuropathy, hyperglycemia, ypercapnia etc.) 13)Not evoled CMAP amplitude in median nerve 14)Patient already performed tracheotomy or tube feeding. 15)Patient with disease duration of less than 36 months at study entry. 16)Patient had family history of amyotorphic lateral sclerosis. 17)Patient already administered other drug (procaine amide, quinidine, aprindine, amoxapine, antiepileptic drug). If patient suspend the administration of these drugs, they had possibility to exacerbate illness.
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