NL-OMON38509
Completed
Not Applicable
Changes in the lymph nodes during the earliest phases of rheumatoid arthritis - Lymph nodes in the earliest phases of rheumatoid arthritis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- arthritis
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 100
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Healthy controls: negative for IgM\-RF and anti\-CCP antibodies
- •Autoantibody\-positive individuals: positive for IgM\-RF and/or anti\-CCP antibodies \+ either arthralgia or a first degree relative with RA.
- •Early arthritis patients: arthritis \< 1 year, disease\-modifying antirheumatic drug (DMARD) naive \+ classified as RA according to the 2010 ACR/EULAR criteria for RA or as unclassified arthritis (UA).
Exclusion Criteria
- •For all individuals:
- •\- Current/previous use of disease modifying anti\-rheumatic drugs (DMARDs).
- •\- If applicable: patients in whom anticoagulant therapy cannot be temporarily stopped before the procedure
- •\- Systemic prednisolone use less then 28 days before enrolment
- •\- Present or previous treatment with any cell depleting therapies, including investigational agents (e.g. CAMPATH, anti\-CD4, anti\-CD5, anti\-CD3, anti\-CD19\)
- •\- Presence of any disease for which study subjects need chronic or intermittent immunosuppressive therapy (e.g. prednisolone for COPD).
- •\- History of chronic viral infection
- •\- History of autoimmune diseases
- •\- History of malignancies
Outcomes
Primary Outcomes
Not specified
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