Evolution of patients who underwent surgery for cancer treatment in Brazil during the COVID-19 pandemic

• Conditions: Postoperative Period; COVID-19; Surgical Oncology; Intraoperative Complications

• Registration Number: RBR-8ygjpqm
• Lead Sponsor: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2023-05-31
• Study Start: 2023-07-11
• Last Update Posted: 26 July 2023

Recruitment & Eligibility

• Status: Data analysis completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

All patients undergoing surgeries for cancer treatment performed between March and June 2019 and between March and June 2020, who underwent postoperative care in the intensive care unit; with a minimum age of 18 years; both genders

Exclusion Criteria

Advanced cancer with no prospective of treatment, severe hepatic failure (Child C); hospital stay less than 12 hours; patients who undergo reoperation before inclusion in the study; readmission to intensive care unit during the same hospital stay of study inclusion; previously included patients; pregnant patients

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Expected outcome 1. It is expected to find an absolute increase from 9% to 25% in the cumulative incidence of death in 28 days in the group of patients operated during the pandemic compared to patients operated in the period before the pandemic. The outcome will be evaluated by analyzing data taken from the participants' electronic medical records. Due to the possibility of imbalances between the groups, adjusted analyzes were performed for the primary outcome using the Cox regression model;Outcome found 1. The proportional hazard ratio for 28-day cumulative mortality in the Cox regression model adjusted for urgent surgery, surgery time, Simplified Acute Physiology Score III, body mass index, sex, age, and institutions, between the 2019 and 2020 periods was 4 .35 (95% CI: 2.15-8.82) for patients from the 2020 period