The effect of resistance training and nano curcumin supplementation on synovial fluid biomarkers
- Conditions
- Knee Osteoarthritis.Primary gonarthrosis, bilateral
- Registration Number
- IRCT20161208031300N1
- Lead Sponsor
- Bojnourd University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 60
Having an OA (primary) knee with a grade of 1 to 4
Low mobility (Participate in sports activities less than three times a week for less than 20 minutes during the past six months and lack of participation in organized activities over the past year)
The age range is between 45-60 years
Non-acute illness like cardiovascular disease and lack of fracture and injury In the lower extremity or a joint infection
Lack of endocrine and metabolic diseases (diabetes, thyroid, kidney, liver), cardiovascular disease (high blood pressure, coronary artery disease and atherosclerosis, peripheral vascular diseases and myocardial infarction), mental illness (depression, Schizophrenia and mania), epilepsy, anemia, cancer and any infectious disease.
No history of alcohol and smoking and any addiction
Unwillingness of patients to continue cooperation in research
No synovial fluid during aspiration
Knee joint limitation and inability to perform sports exercises
Any injuries when doing exercises
Taking medications other than diclofenac for the treatment of osteoarthritis
Suffering from cardiovascular, liver, diabetes, kidney failure
Age range less than 45 and more than 60 years
Addiction and alcohol and smoking
Joint infection
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method evels of synovial fluid biomarkers of the knee. Timepoint: 24 hours before the intervention and 48 hours after the end of the intervention. Method of measurement: Enzyme-Linked Immunosorbent Assay test.
- Secondary Outcome Measures
Name Time Method Knee pain. Timepoint: 24 hours before the intervention and 24 hours after the intervention. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index,Visual Analogue Scale.;Improving the quality of life. Timepoint: 24 hours before the intervention and 24 hours after the intervention. Method of measurement: Health Assessment Questionnaire.