Endothelial Glycocalyx Evaluated on Release of the Endothelial Glycocalyx Proteins and Salt Blood Test in Patients With Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 137
- 主要终点
- Erythrocyte Salt Sensitivity
研究概览
简要总结
The luminal side of the entire vasculature is covered with a gel-like polymer called endothelial glycocalyx (EG). EG is important for the transport of molecules in and out of the blood cells and for endothelial function. EG protects the blood vessel wall, is likely to contribute to maintenance of normal blood pressure and the prevention of blood clot formation. Overall it is likely to avoid development of cardiovascular disease.
A newly developed blood test, salt-blood test, can measure erythrocyte salt sensitivity and gives information about the condition of EG. EG can also be measured by release of endothelial glycocalyx proteins.
Previous studies indicate that this EG is impaired by a number of chronic diseases, including chronic kidney disease. This study investigates the quality of glycocalyx in patients with chronic kidney disease, and compares with the layer in healthy.
详细描述
The purpose of this study is to gain knowledge about how pronounced the EG are affected in varying degrees of chronic kidney disease compared with healthy controls assessed by
- salt-blood test
- release of endothelial glycocalyx proteins.
and to see how this correlates to
- blood pressure (peripheral and central)
- pulse wave velocity
- albuminuria
- coagulation system
- vasoactive hormones (PRC, p-Ang-II, p-Aldo, p-ANP, p-BNP, p-AVP)
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Erythrocyte Salt Sensitivity
时间窗: 1 minute
Blood sample
次要结局
- Syndecan-1(1 minute)
- Heparan Sulfate(1 minute)
- Vasoactive hormones (PRC, Ang-II, Aldo, ANP, BNP, AVP)(1 minute)
- coagulation(1 minute)
- blood pressure central and peripheral(1 minute)
- pulse wave velocity(1 minute)
- Albuminuria(1 minute)
研究者
Jesper Norgaard Bech
Chief Physician and PhD
Regional Hospital Holstebro