Safety and Effectiveness of Ticagrelor in Patients Undergoing Carotid Stenting

Phase 1

• Conditions: Carotid Stenosis
• Interventions: Drug: Ticagrelor; Drug: Clopidogrel; Procedure: Carotid stenting

• Registration Number: NCT04091074
• Lead Sponsor: Assiut University

Brief Summary

patients undergoing carotid stenting take dual anti platelet therapy to prevent thrombotic complications usually used drugs are aspirin plus clopidogrel but there are patients not respond so ticagrelor may be an effective and safe alternative

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-09-12
• Study First Submitted QC: 2019-09-13
• Study First Posted: 2019-09-16
• Status Verified: 2021-03
• Last Update Submitted: 2021-03-22
• Last Update Posted: 2021-03-23
• Study Start: 2022-01-01
• Primary Completion: 2022-12-01
• Study Completion: 2022-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 26

Inclusion Criteria

1. Ischemis stroke of both sex.
2. More than 18 years.
3. Accepting all study requirements.

Exclusion Criteria

1. Refuse to comply with all study requirements.
2. bleeding tendency or liver diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
aspirin + clopidogrel before carotid stenting	Carotid stenting	patients undergoing carotid stenting take aspirin 150 mg + clopidogrel 75 mg for 15 days before carotid stenting
aspirin + ticagrelor before carotid stenting	Carotid stenting	patients undergoing carotid stenting take aspirin 150 mg + ticagrelor 90mg for 15 days before carotid stenting
aspirin + ticagrelor before carotid stenting	Ticagrelor	patients undergoing carotid stenting take aspirin 150 mg + ticagrelor 90mg for 15 days before carotid stenting
aspirin + clopidogrel before carotid stenting	Clopidogrel	patients undergoing carotid stenting take aspirin 150 mg + clopidogrel 75 mg for 15 days before carotid stenting

Primary Outcome Measures

Name	Time	Method
compare efficacy of ticagrelor and clopidogrel in patients undergoing carotid stenting	15 days before carotid stenting	patients undergoing carotid stenting are divided into 2 groups comparing efficacy of ticagrelor and clopidogrel
Compare safety of ticagrelor and clopidogrel in patients undergoing carotid stenting	15 days before carotid stenting	Patients undergoing carotid stenting are divided into two groups comparing safety of ticagrelor and clopidogrel

Secondary Outcome Measures

Name	Time	Method
Pattern of carotid stenosis	1 year	Incidence of carotid stenosis in patients come to Assiut university hospitals