Neuromuscular Responses, Pain Intensity and Perceived Exertion of Resistance Exercise With Blood Flow Restriction in Patients With Severe Knee Osteoarthritis
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Valencia
- Enrollment
- 22
- Locations
- 1
- Primary Endpoint
- Self-reported pain intensity (Visual Analogue Scale (VAS) Scale 0-10)
Study Overview
Brief Summary
The purpose of this study is to evaluate the neuromuscular responses, pain intensity and rate of perceived exertion in patients with severe knee osteoarthritis in a preoperative setting with low-load resistance training with blood flow restriction at different levels of arterial occlusion pressure.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 55 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •men and women above 55 years old.
- •diagnosed with severe knee osteoarthritis.
- •scheduled for unilateral TKA surgery in a local hospital during 2021- 2022.
Exclusion Criteria
- •pain in the contralateral limb (maximum pain, ≥80 of 100 mm on a VAS during daily activities).
- •another hip or knee joint replacement in the previous year.
- •any medical condition in which exercise was contraindicated.
- •participated in exercise programs (>2 days/week, training at intensities of 10-15RM) in the 6 months prior to the study.
- •history of stroke, brain surgery, major depression, or any self-perceived cognitive alterations that could affect the performance of dual tasks.
Arms & Interventions
Placebo
Knee extensions with 30% 1RM and no occlusion pressure.
Intervention: BFR resistance exercise (Other)
BFR at 40% AOP
Knee extensions with 30% 1RM and BFR at 40% AOP.
Intervention: BFR resistance exercise (Other)
BFR at 80% AOP
Knee extensions with 30% 1RM and BFR at 80% AOP.
Intervention: BFR resistance exercise (Other)
Outcomes
Primary Outcomes
Self-reported pain intensity (Visual Analogue Scale (VAS) Scale 0-10)
Time Frame: Pre exercise, immediate post set, immediate post session, and 10 minutes after session.
Change from baseline to the end of the session, and the change between the treatment group and the placebo group.
HDsEMG
Time Frame: During each experimental session and during each exercise condition.
Change between baseline and exercise, and the change between the treatment group and the placebo group.
Pressure pain thresholds
Time Frame: Pre exercise, immediate post session, and 10 minutes after session.
Change from baseline to the end of the session, and the change between the treatment group and the placebo group.
Secondary Outcomes
- Tampa Scale of Kinesiophobia (TSK 11)(Pre session.)
- Chronic Pain Self-Efficacy Scale (CPSS)(Pre session.)
- Pain Catastrophizing Scale (PCS)(Pre session.)
- Heart Rate(Pre exercise, immediate post set, immediate post session, and 10 minutes after session.)
- WOMAC questionaire for patients with hip or knee osteoarthritis.(Pre session.)
- Rating of perceived exertion (RPE) based on Borg's CR10 scale(Immediate post exercise.)
Investigators
José Casaña Granell
Head of the Physiotherapy Department
University of Valencia