Efficacy of Xenograft Alone or Mixed With Arginyl-Glycyl-Aspartic Acid (RGD) in Horizontal Ridge Augmentation With Split-crest Technique for Implant Placement

Not Applicable

Recruiting

• Conditions: Implant Dentistry
• Interventions: Drug: Xenograft; Drug: RGD; Procedure: Split crest technique

• Registration Number: NCT06585852
• Lead Sponsor: Al-Azhar University

Brief Summary

The aim of the present study is to evaluate the efficacy of xenograft alone or xenograft mixed with Arginylglycylaspartic acid (RGD) , in horizontal ridge augmentation with split-crest technique, for implant placement.

Detailed Description

A comparative study for ridge augmentation procedure, With two groups. First group underwent a surgical ridge splitting procedure with ultrasonic bone surgery and grafting with Xenograft alone and implant placement. Second group underwent a surgical ridge splitting procedure with ultrasonic bone surgery Xenograft mix ed with Arginylglycylaspartic acid (RGD) and implant placement.

Both groups were followed up for 1 and 3 months after loading.

Study Timeline

• Study Start: 2023-08-01
• Status Verified: 2024-09
• Primary Completion: 2024-09-01
• Study First Submitted: 2024-09-01
• Study First Submitted QC: 2024-09-03
• Last Update Submitted: 2024-09-03
• Study First Posted: 2024-09-06
• Last Update Posted: 2024-09-06
• Study Completion: 2024-10-15

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 18

Inclusion Criteria

1. Adults (age 18-30) exhibiting initial insufficiently bone width.
2. Patients with good oral hygiene.
3. Patients must be free from systemic diseases that may influence the outcome of the therapy.
4. Patients with bony horizontal defects alone, Class III & IV.

Exclusion Criteria

1. Heavy smokers.
2. Patient treated by immunosuppressive chemotherapy or radio therapy,
3. Allergy to any material or medication used in the study.
4. Pregnant females.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control Group	Xenograft	Xenograft alone with split-crest technique by ultrasonic bone surgery and implant placement.
Control Group	Split crest technique	Xenograft alone with split-crest technique by ultrasonic bone surgery and implant placement.
Study Group	RGD	Xenograft mixed with RGD with split-crest technique by ultrasonic bone surgery and implant placement.
Study Group	Xenograft	Xenograft mixed with RGD with split-crest technique by ultrasonic bone surgery and implant placement.
Study Group	Split crest technique	Xenograft mixed with RGD with split-crest technique by ultrasonic bone surgery and implant placement.

Primary Outcome Measures

Name	Time	Method
ISQ measurement for implant stability	At time of surgery, at loading and 3 months after loading.	Evaluate implant stability by osstell device

Secondary Outcome Measures

Name	Time	Method
Bone density around dental implants.	At time of loading and 3 months after loading	Evaluation of bone density after ridge splitting and implant placement

Trial Locations

Locations (1)

Al Azhar University of Cairo; 🇪🇬 Cairo, Nasr City, Egypt