The frontotemporal syndrome in amyotrophic lateral sclerosis: screen, impact, imaging and pathology.
- Conditions
- binnen zenuwstelsel aandoeningen: dementie van het frontotemporale type (FTD)amyotrophic lateral sclerosis (ALS)Motor neuron disease (MND)10029317
- Registration Number
- NL-OMON44137
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 181
Age >= 18 years, speak Dutch fluently, have a proxy (partner, family member or close friend) who speaks Dutch fluently and is willing to fill in the questionnaires.
Furthermore, ALS patients must have sporadic or familial (fALS), probable, probable-laboratory supported or definite ALS, as defined by the El Escorial criteria, with a symptom duration of less than 12 months. ALS-FTD and behaviour variant-FTD patients must have sporadic or familial, probable or definite bv-FTD, as defined by the Neary criteria and the revised criteria by Rascovsky et al.
Any neurological or psychiatric condition with cognitive impairment or behavioural changes, use of psychopharmaca, excessive alcohol intake, i.e. >= 5 drinks per day, forced vital capacity < 70% of the predicted value in the upright position, at the time of inclusion (ALS patients), incapacitated person.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. A validated, short cognitive screening instrument for ALS patients.<br /><br>2. Differences in structural and functional brain networks (connectivity<br /><br>measures) between patients with and without a frontotemporal syndrome.</p><br>
- Secondary Outcome Measures
Name Time Method <p>1. An estimate of the impact of ALS and the frontotemporal syndrome on the<br /><br>patient and their carers.<br /><br>2. A brainbank of phenotyped ALS patients.</p><br>