A prospective cohort for ex vivo cure studies with chronic HIV infected patients in the Netherlands: The CHRONO project

Recruiting

• Conditions: AIDS; HIV; 10047438

• Registration Number: NL-OMON49028
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 45

Inclusion Criteria

Adult chronic HIV infected patients of >=18 years of age who initiate
antiretroviral therapy in routine care.

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded
from participation in this study:
1. Inability to place venous catheters to draw blood.
2. Major comorbidities:
a. Severe symptomatic anemia or recent symptomatic cardiovascular event
(unstable angina pectoris, decompensated heart failure, myocardial infarction).
b. The inability to participate due to any other relevant social,
environmental, psychological, factors or according to the HIV treating
physician*s judgement.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. The evolution in reservoir size ex vivo as assessed as the number of cells<br /><br>expressing viral RNA and viral protein Gag (vRNA/prGag +/+) in HIV patients on<br /><br>cART at week 24 and 48 after treatment initiation.</p><br>