Out of hospital cardiac arrest outcomes

Not Applicable

• Conditions: Out of hospital cardiac arrest; Circulatory System

• Registration Number: ISRCTN10428536
• Lead Sponsor: niversity of Warwick

Brief Summary

2015 Protocol article in https://bmjopen.bmj.com/content/5/10/e008736 protocol (added 23/01/2019)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-02-03
• Last Update Posted: 20 November 2023
• Study Completion: 2028-10-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 35000

Inclusion Criteria

Current inclusion criteria as of 22/01/2019:
1. Adults and children (all ages)
2. Out-of-hospital cardiac arrest
3. Attended by or on behalf of an NHS Ambulance Service
4. Resuscitation attempted

Previous inclusion criteria:
Patients will be enrolled if after initial screening they fulfil the following criteria:
1. Out of hospital cardiac arrest
2. Resuscitation is attempted (Advanced or Basic Life Support)commenced/ continued by ambulance service

Exclusion Criteria

Current participant exclusion criteria as of 10/11/2023:
1. Cardiac arrests during inter-hospital transfer or on acute NHS hospital trust premises
2. Where there is clear evidence of death defined by the Joint Royal College Ambulance Liaison Committee (JRCALC) Recognition of life extinct (ROLE) criteria

Previous participant exclusion criteria:
1. Arrest during inter­hospital transfer or on acute NHS hospital trust premises
2. Patients with clear evidence of death defined by the Joint Royal College Ambulance Liaison Committee (JRCALC)
3. Recognition of life extinct (ROLE) criteria
Criteria for ROLE:
3.1. Massive cranial and cerebral destruction
3.2. Hemicorporectomy
3.3. Massive truncal injury incompatible with life (including decapitation)
3.4. Decomposition/putrefaction
3.5. Incineration
3.6. Hypostasis
3.7. Rigor mortis
4. A valid do not attempt resuscitation (DNAR) order or an Advanced Directive (Living Will) that states the wish of the patient not to undergo attempted resuscitation
5. When the patient’s death is expected due to terminal illness
6. Efforts would be futile, as defined by the combination of all three of the following being present:
6.1. More than 15 minutes since the onset of collapse
6.2. No bystander CPR prior to arrival of the ambulance
6.3. Asystole (flat line) for >30 seconds on the ECG monitor screen. Exceptions are drowning, drug overdose/poisoning, trauma
7. Submersion of adults for longer than 1 hour

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<br> Summary data collection: For each case we will collect information from the ambulance clinical record about the time and location of the incident, information about the patient (age, sex, race) the time taken for the ambulance to arrive, the presumed cause of the cardiac arrest, the initial heart rhythm, treatments administered by bystanders and trained ambulance staff.<br> Main outcome measurements:<br> 1. Initial survival (Return of spontaneous circulation i.e. restoring the heartbeat)<br> 2. Medium – long term survival (30 days – 10 year survival). We will obtain this information from the ambulance service (initial survival) and the Medical Research Information Service (MRIS) (medium to long term survival)<br>

Secondary Outcome Measures

Name	Time	Method
<br> 1. The optimal process for case identification and outcome verification following OHCA<br> 2. Factors which influence survival from OHCA in the UK and are feasible to include in risk prediction modelling<br> 3. Feasibility of establishing a national OHCA registry in the UK<br>