The Relationship Between Systemic Immune Inflammation Index and Disease Activity in Patients With Ankylosing Spondylitis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Ankylosing Spondylitis
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Platelet to-lymphocyte ratio (PLR)
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
In this study, the aim was to investigate the relationship between SII and other laboratory parameters with disease activity in AS patients and to discuss its usability in the follow-up and treatment process.
Detailed Description
This study aimed to investigate the relationship between the systemic immune inflammation index (SII), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), and disease activity and functional status in patients with ankylosing spondylitis (AS). A cross-sectional clinical study was conducted, and a total of 90 patients diagnosed with AS according to the Modified New York Criteria, aged between 18 and 65, who presented to our outpatient clinics were included in the study. Demographic data, disease duration, age at symptom onset, and laboratory parameters, including platelet, neutrophil, basophil, eosinophil, lymphocyte counts, mean platelet volume (MPV), red blood cell distribution width (RDW), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR), were recorded. NLR and PLR values were calculated. The Systemic Immune Inflammation Index (SII) was calculated by dividing the product of neutrophil and platelet counts by the lymphocyte count. We investigated all of these parameters and disease activity scores. Disease activity was assessed with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), spinal mobility with the Bath Ankylosing Spondylitis Metrology Index (BASMI), and functional status with the Bath Ankylosing Spondylitis Functional Index (BASFI). In addition, during the routine follow-ups of patients, requested blood tests were examined, and platelet, neutrophil, basophil, eosinophil, lymphocyte counts, mean platelet volume (MPV), RDW (red blood distribution width), CRP, and ESR values will be recorded. Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic immune inflammation index (SII) were calculated
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients between the ages of 18 and 65 who have been diagnosed with Ankylosing Spondylitis according to the Modified New York Criteria, have applied to the Istanbul Physical Medicine and Rehabilitation Training and Research Hospital outpatient clinic on the specified dates, meet the exclusion criteria, and have complete blood count, CRP, and ESR values in their hospital records.
Exclusion Criteria
- •Presence of acute or chronic infection
- •Presence of autoimmune diseases other than Ankylosing Spondylitis
- •Pregnancy
- •Chronic kidney disease
- •Chronic liver disease
- •Malignancy
- •Cardiovascular disease
- •Hematological disease
Outcomes
Primary Outcomes
Platelet to-lymphocyte ratio (PLR)
Time Frame: through study completion, an average of 1 month
PLR is a ratio between the absolute platelet count and absolute lymphocyte count.
Neutrophil-to-lymphocyte ratio (NLR)
Time Frame: through study completion, an average of 1 month
NLR is a ratio between the absolute neutrophil count and absolute lymphocyte count.
The Systemic Immune Inflammation Index (SII)
Time Frame: through study completion, an average of 1 month
The Systemic Immune Inflammation Index (SII) was calculated by dividing the product of neutrophil and platelet counts by the lymphocyte count.
Mean platelet volume (MPV)
Time Frame: through study completion, an average of 1 month
MPV blood test measures the average size of patient's platelets
Red blood cell distribution width (RDW)
Time Frame: through study completion, an average of 1 month
A red cell distribution width (RDW) test measures the differences in the volume and size of the red blood cells (erythrocytes).
Secondary Outcomes
- The Bath Ankylosing Spondylitis Metrology Index(through study completion, an average of 1 month)
- The Bath Ankylosing Spondylitis Disease Activity Index(through study completion, an average of 1 month)
- The Bath Ankylosing Spondylitis Functional Index(through study completion, an average of 1 month)
- Ankylosing Spondylitis Disease Activity Score with erythrocyte sedimentation rate(through study completion, an average of 1 month)
- Ankylosing Spondylitis Disease Activity Score with c-reactive protein(through study completion, an average of 1 month)
- C-reactive protein(through study completion, an average of 1 month)
- Erythrocyte sedimentation rate(through study completion, an average of 1 month)