Triple Negative Breast Cancer and Germline Hereditary Breast and Ovarian Cancer Mutation Carrier Registry

Recruiting

• Conditions: Hereditary Breast and Ovarian Cancer; Breast Cancer

• Registration Number: NCT02302742
• Lead Sponsor: University of Kansas Medical Center

Brief Summary

PROGECT is a registry for patients with Triple Negative breast cancer (TNBC) or patients who have an identified germline mutations (such as a mutation on the BRCA1 or BRCA2 genes).

Detailed Description

This study is being done to collect cancer-related information from patients with triple negative breast cancer and patients with hereditary genetic mutations. This information will help us better understand the link between genetic changes and cancer outcome in patients with triple negative breast cancer.

Study Timeline

• Study Start: 2011-03-22
• Study First Submitted: 2014-11-11
• Study First Submitted QC: 2014-11-24
• Study First Posted: 2014-11-27
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-08
• Last Update Posted: 2023-05-09
• Primary Completion: 2024-12
• Study Completion: 2025-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1500

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence of germline mutations (such as BRCA1/2 mutations) in patients with TNBC	5 years
. Predictors of response to neo/adjuvant chemotherapy in patients with TNBC	5 years
Long term Disease free and overall survival rates in TNBC patients treated with different systemic therapies	10 years

Trial Locations

Locations (13)

Menorah Medical Center; 🇺🇸 Overland Park, Kansas, United States

The University of Kansas Cancer Center; 🇺🇸 Westwood, Kansas, United States

KCCC West; 🇺🇸 Kansas City, Kansas, United States

Salina Regional Health Center - Tammy Walker Cancer Center; 🇺🇸 Salina, Kansas, United States

Research Medical Center; 🇺🇸 Kansas City, Missouri, United States

KCCC - North; 🇺🇸 Kansas City, Missouri, United States

KCCC Overland Park; 🇺🇸 Overland Park, Kansas, United States

Overland Park Regional Medical Center; 🇺🇸 Overland Park, Kansas, United States

Hays Medical Center Dreiling-Schmidt Cancer Institute; 🇺🇸 Hays, Kansas, United States

Centerpoint Regional Medical Center; 🇺🇸 Independence, Missouri, United States

Truman Medical Center; 🇺🇸 Kansas City, Missouri, United States

KCCC South; 🇺🇸 Kansas City, Missouri, United States

KCCC Lee's Summit; 🇺🇸 Lee's Summit, Missouri, United States