The effects of cinacalcet hydrochloride on the regression of the parathryoid gland hyperplasia
Not Applicable
- Conditions
- Secondary hyperparathyroidism under hemodialysis therapy
- Registration Number
- JPRN-UMIN000004212
- Lead Sponsor
- Department of Chronic Kidney Disease, Graduate School of Medical Science, Kyushu University
- Brief Summary
Two years of treatment with cinacalcet hydrochloride significantly decreased parathryoid gland volumes, independent of the baseline PTH values and parathyroid gland volumes in 60 hemodialysis patients with secondary hyperparathyroidism. During the treatment period, serum PTH valuse increased in some patients, indicating that some patients showed resistance to cinacalcet treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Not provided
Exclusion Criteria
Patients who have a past history of surgical parathyroidectomy and percutaneous ethanol injection therapy are excluded. In addition, patients who have been suffered from lifethreatening medical conditios such as malignancy or severe infection.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The changes in parathyroid gland volume after cinacalcet hydrochloride treatment
- Secondary Outcome Measures
Name Time Method Serial changes in the serum levels of intact PTH, corrected calcium, phosphorus and alkaline phosphatase, and in the doses of drugs used for secondary hyperparathyroidism