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Clinical Trials/ACTRN12618000561280
ACTRN12618000561280Completed未知

Relation between chronic endometritis and recurrent miscarriage

Department of Obstetrics and Gynecology, Ahmadi hospital, Kuwait.0 sites110 target enrollmentStarted: April 13, 2018Last updated:

Trial Snapshot

Phase
未知
Status
Completed
Sponsor
Enrollment
110

Study Overview

Brief Summary

Summary of results: The prevalence of chronic endometritis in women with recurrent miscarriage was 31.8% using chronic endometritis-related hysteroscopic signs, while it was 38.2% using immunohistochemical staining and endometrial cultures (p = 0.4). Chronic endometritis-related hysteroscopic signs had 64.1% sensitivity, 85.9% specificity, 71.4% positive predictive value (PPV), 81.3% negative predictive value (NPV), and 78.2% overall accuracy in diagnosing chronic endometritis. Most cases of chronic endometritis (> 81%) were caused by Mycoplasma and common pathogens.

Study Design

Study Type
Interventional
Allocation
Non-randomised trial
Primary Purpose
Diagnosis

Eligibility Criteria

Ages
20 Years to 40 Years (—)
Sex
Female

Inclusion Criteria

  • Patients and methods: Analysis of the hospital records over the last 5 years from January 2012 to January 2017 to identify women with unexplained recurrent miscarriage, after approval of the Obstetrics and Gynecology department.
  • Inclusion criteria includes; women who will give consent, >20-40 years, with 3 or more miscarriages before 22 weeks’ gestation.

Exclusion Criteria

  • Exclusion criteria includes; family history of RM, uterine abnormalities, hormonal or metabolic disorders, severe male factor infertility, previous surgery for myoma and/or endometriosis, clinical or ultrasound diagnosis of endometriosis, known clinical autoimmune disease, anti-phospholipid syndrome (APS), thrombophilic condition requiring anticoagulant therapy, and unwilling to give informed consent.

Investigators

Sponsor
Department of Obstetrics and Gynecology, Ahmadi hospital, Kuwait.

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