Relation between chronic endometritis and recurrent miscarriage
- Conditions
- Chronic endometritisReproductive Health and Childbirth - Antenatal careReproductive Health and Childbirth - Fetal medicine and complications of pregnancy
- Registration Number
- ACTRN12618000561280
- Lead Sponsor
- Department of Obstetrics and Gynecology, Ahmadi hospital, Kuwait.
- Brief Summary
Summary of results: The prevalence of chronic endometritis in women with recurrent miscarriage was 31.8% using chronic endometritis-related hysteroscopic signs, while it was 38.2% using immunohistochemical staining and endometrial cultures (p = 0.4). Chronic endometritis-related hysteroscopic signs had 64.1% sensitivity, 85.9% specificity, 71.4% positive predictive value (PPV), 81.3% negative predictive value (NPV), and 78.2% overall accuracy in diagnosing chronic endometritis. Most cases of chronic endometritis (> 81%) were caused by Mycoplasma and common pathogens.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 110
Patients and methods: Analysis of the hospital records over the last 5 years from January 2012 to January 2017 to identify women with unexplained recurrent miscarriage, after approval of the Obstetrics and Gynecology department.
Inclusion criteria includes; women who will give consent, >20-40 years, with 3 or more miscarriages before 22 weeks’ gestation.
Exclusion criteria includes; family history of RM, uterine abnormalities, hormonal or metabolic disorders, severe male factor infertility, previous surgery for myoma and/or endometriosis, clinical or ultrasound diagnosis of endometriosis, known clinical autoimmune disease, anti-phospholipid syndrome (APS), thrombophilic condition requiring anticoagulant therapy, and unwilling to give informed consent.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method