ACTRN12618000561280Completed未知
Relation between chronic endometritis and recurrent miscarriage
Department of Obstetrics and Gynecology, Ahmadi hospital, Kuwait.0 sites110 target enrollmentStarted: April 13, 2018Last updated:
Trial Snapshot
- Phase
- 未知
- Status
- Completed
- Sponsor
- Enrollment
- 110
Study Overview
Brief Summary
Summary of results: The prevalence of chronic endometritis in women with recurrent miscarriage was 31.8% using chronic endometritis-related hysteroscopic signs, while it was 38.2% using immunohistochemical staining and endometrial cultures (p = 0.4). Chronic endometritis-related hysteroscopic signs had 64.1% sensitivity, 85.9% specificity, 71.4% positive predictive value (PPV), 81.3% negative predictive value (NPV), and 78.2% overall accuracy in diagnosing chronic endometritis. Most cases of chronic endometritis (> 81%) were caused by Mycoplasma and common pathogens.
Study Design
- Study Type
- Interventional
- Allocation
- Non-randomised trial
- Primary Purpose
- Diagnosis
Eligibility Criteria
- Ages
- 20 Years to 40 Years (—)
- Sex
- Female
Inclusion Criteria
- •Patients and methods: Analysis of the hospital records over the last 5 years from January 2012 to January 2017 to identify women with unexplained recurrent miscarriage, after approval of the Obstetrics and Gynecology department.
- •Inclusion criteria includes; women who will give consent, >20-40 years, with 3 or more miscarriages before 22 weeks’ gestation.
Exclusion Criteria
- •Exclusion criteria includes; family history of RM, uterine abnormalities, hormonal or metabolic disorders, severe male factor infertility, previous surgery for myoma and/or endometriosis, clinical or ultrasound diagnosis of endometriosis, known clinical autoimmune disease, anti-phospholipid syndrome (APS), thrombophilic condition requiring anticoagulant therapy, and unwilling to give informed consent.
Investigators
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