Cross-education by Unilateral Resistance Training Preserves Skeletal Muscle Mass and Strength During Immobilization in Patients Undergoing Clavicle Fracture Surgery. A Pilot Randomized Controlled Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Change in muscle thickness of the biceps brachii, triceps brachii and supraspinatus muscles by ultrasound.
研究概览
简要总结
The immobilization process after an operation or injury in the upper extremity causes a loss of muscle mass and strength of 0.2% and 1.3% per day, respectively. Currently, the use of cross-education, which is unilateral training in the uninjured limb, during the immobilization period, is expanding, demonstrating a magnitude of strength gain in the immobilized limb from 8% to 77% of the mean of strength of the trained limb. Despite the evidenced benefits of cross-education in unilateral injuries such as distal radius fracture, anterior cruciate ligament injury, and knee replacement, very little is known about this effect in shoulder immobilization after clavicle fracture.
详细描述
Objective
: To determine the effects of unilateral resistance exercise training of the uninjured limb on skeletal muscle mass, strength, pain, and disability in the immobilized limb after immobilization (4 weeks) and after standard physiotherapy (8 weeks) in patients undergoing clavicle fracture surgery.
Methodology: Nineteen men (27 ± 5 years) were randomly to a control group (n = 8; immobilization + standard physiotherapy) or experimental group (n = 11; immobilization + unilateral resistance training of the uninjured limb + standard physiotherapy). Outcomes included biceps brachii muscle thickness (ultrasonography), elbow flexion strength (1RM estimate), disability (Quick Dash questionnaire) and pain (visual analog scale), assessed at 4- and 8-week post-clavicle surgery.
Expected results: It is expected to observe a gain in muscle mass and strength in the trained limb and a maintenance/gain of muscle mass and strength in the group that perform cross-training during the immobilization period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
盲法说明
single-blind study
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •(i) male sex, (ii) age 18-40 years (iii), surgically treated mid-clavicular fracture, (iv) body mass index 18.5-30.0 kg/m2, and (v) physically active status.
- •The study focused on male participants to minimize variability related to sex-specific neuromuscular and morphological responses
排除标准
- •(i) previous upper-limb fractures or polytrauma, (ii) surgical delay >12 days, (iii) cardiovascular conditions contraindicating exercise, (iv) uncontrolled comorbidities, (v) neurological injury, (vi) smoking, and (vii) use of nutritional supplements known to affect muscle metabolism (i.e., creatine, leucine, glutamine, casein, whey protein, fatty acids, etc.).
研究组 & 干预措施
standard physical therapy
Men with clavicle fracture immobilized for 4 weeks + standard physical therapy for 8 weeks
干预措施: standard physical therapy (Other)
结局指标
主要结局
Change in muscle thickness of the biceps brachii, triceps brachii and supraspinatus muscles by ultrasound.
时间窗: before surgery, after 6 and 12 weeks postoperatively
Change in muscle thickness of the biceps brachii, triceps brachii and supraspinatus muscles by ultrasound.
次要结局
- Upper and middle arm circumference change in both posterior arms(before surgery, after 6 and 12 weeks postoperatively)
- Change in grip strength using a dynamometer and change in manual force at 90º elbow flexion, 45º shoulder flexion and 0º shoulder abduction(before surgery, after 6 and 12 weeks postoperatively)
- Change in relation to pain using the visual analogue scale(before surgery, after 6 and 12 weeks postoperatively)
- Change in range of motion in elbow flexion, shoulder flexion, shoulder abduction, and rotations.(before surgery, after 6 and 12 weeks postoperatively)
- Change in functionality using the Quick Dash questionnaire(before surgery, after 6 and 12 weeks postoperatively)
研究者
Gabriel Nasri Marzuca-Nassr
PhD
Universidad de La Frontera