Fractional Laser Versus Radiofrequency in Androgenetic Alopecia

Not Applicable

• Conditions: Androgenic Alopecia
• Interventions: Procedure: FCO2; Procedure: FRF

• Registration Number: NCT05435625
• Lead Sponsor: Kasr El Aini Hospital

Brief Summary

Patients with Androgenetic alopecia will be randomized into 2 groups; Group FCO2 receiving Fractional CO2 or Group FRF receiving Fractional Microneedling Radiofrequency.

Detailed Description

Group FCO2 will be to receiving fractional CO2 to one randomized side of the scalp, and Group FRF will be receiving Fractional Microneedling radiofrequency to one randomized side of the scalp.

All patients will receive 4 sessions with 4-week intervals.each session will be followed by immediate topical application of 6 puffs (=1 mL) of minoxidil 5% solution twice daily and also in between the sessions and during follow up period

Study Timeline

• Study Start: 2022-01-01
• Study First Submitted: 2022-03-11
• Status Verified: 2022-06
• Study First Submitted QC: 2022-06-23
• Last Update Submitted: 2022-06-23
• Study First Posted: 2022-06-28
• Last Update Posted: 2022-06-28
• Primary Completion: 2022-09-01
• Study Completion: 2022-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• • both genders are included.

  • Patients above 18 years old.

Exclusion Criteria

• • Patients with patchy hair loss.

  • Patients with Telogen Effluvium or diffuse alopecia areata.
  • Patients with cicatricial alopecias.
  • Patients with associated inflammatory scalp disorders such as psoriasis or seborrheic dermatitis.
  • Patients with collagen vascular disorders.
  • Prior use of topical steroids on scalp in the previous 2 weeks.
  • Prior use of systemic steroids in the previous 1 month.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
FCO2	FCO2	Fractional Carbon dioxide laser
FRF	FRF	Fractional Microneedling Radiofrequency

Primary Outcome Measures

Name	Time	Method
Patient satisfaction	6months-1 year	Participants will be also asked to give their assessment on a scale of 4, (0) no satisfaction (1) slight satisfation, (2) moderate satisfaction, (3) marked satisfaction. A higher numerical means a better outcome.
Clinical Global improvement Assessment	6months-1 year	Photographs will be taken with a Canon camera under controlled light in approximately the same position, taken at baseline, after 4 treatment sessions (16 weeks post treatment) and 2 months after follow-up (24 weeks post treatment). Second clinical assessment will be performed based on the clinical change from 16 weeks post treatment to 24 weeks post treatment. Change in the clinical will be measured on a 6 point scale; (-1) worsening, (0) no improvement, (1) less than 25% improvement, (2) 25-50% improvement, (3) 50-75% improvement, (4) more than 75% improvement. A higher numerical means a better outcome.
Phototrichogram assessment.	2 months	A phototrichogram system (Dino-Lite; AnMo Electronics, Taiwan)will be used to evaluate the thickness of hairs. A higher numerical means a better outcome.

Trial Locations

Locations (1)

Kasr Al Ainy Hospital; 🇪🇬 Cairo, El Manial, Egypt