Effects of Phytonutrients Upon Muscle Perfusion in Response to Feeding

Not Applicable

Completed

• Conditions: Biological Aging
• Interventions: Other: Curcuminoid Cohort 2; Other: Catechin Cohort 1; Other: Flavonoid Cohort 3

• Registration Number: NCT03213340
• Lead Sponsor: Abbott Nutrition

Brief Summary

This is a random order cross over design trial to evaluate the efficacy of select nutritional ingredients on enhancing muscle perfusion in response to an acute meal stimulus.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-06-26
• Study First Submitted QC: 2017-07-07
• Study First Posted: 2017-07-11
• Study Start: 2017-09-14
• Primary Completion: 2019-10-02
• Study Completion: 2019-10-02
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-29
• Last Update Posted: 2020-01-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 39

Inclusion Criteria

• Body mass index (BMI) 18-30 kg/m2
• Free from active metabolic disease
• Normotensive

Exclusion Criteria

• Habitual gym use or formal exercise (more than once a week) or other routine strenuous physical activity
• Smokers
• Surgery within past 3 months
• Active cardiovascular disease
• Taking beta-adrenergic blocking agents
• Cerebrovascular disease:
• Active respiratory disease
• Active metabolic disease
• Active inflammatory bowel or renal disease
• Active Malignancy or until confirmed remission
• Clotting dysfunction
• History of DVT
• Significant musculoskeletal or neurological disorders
• Family history of early (<55y) death from cardiovascular disease
• Known sensitivity to Sonovue contrast agent
• Known allergy or intolerance to any of the study ingredients
• Current use of any of the study ingredients

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Curcuminoid Cohort 2	Curcuminoid Cohort 2	2 treatment - Experimental Curcuminoid Blend; Control 1 Placebo
Catechin Cohort 1	Catechin Cohort 1	2 treatment - Experimental Catechin Blend; Control 1 Placebo
Flavonoid Cohort 3	Flavonoid Cohort 3	2 treatment - Experimental Flavonoid Blend; Control 2 Low-Flavonoid Blend

Primary Outcome Measures

Name	Time	Method
muscle microvascular blood flow	Baseline to 240 minutes	contrast enhanced ultrasound

Secondary Outcome Measures

Name	Time	Method
muscle macrovascular blood flow	Baseline to 240 minutes	doppler ultrasound
central vascular blood flow	Baseline to 90 minutes	echocardiography
endothelial function	Baseline to 120 minutes	flow mediated dilation
cerebral blood flow	Baseline to 120 minutes	doppler ultrasound

Trial Locations

Locations (1)

University of Nottingham; 🇬🇧 Derby, United Kingdom