Phospholipid Absorption of a Milk Phospholipid

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Dietary Supplement: Milk phospholipid

• Registration Number: NCT01327430
• Lead Sponsor: University of Jena

Brief Summary

The aim of the study is to investigate parameters of the lipid metabolism in plasma and feces of healthy subjects after a dietary supplementation of different dosages of milk phospholipids.

Detailed Description

To date the mechanisms for the intestinal absorption of glycerophosphates and sphingolipids are not completely investigated. It is assumed, that sphingolipids and sterols compete for intestinal absorption. In addition it is unclear, if a dietary phospholipid supplementation may influence the phospholipid concentration in plasma.

To evaluate the effect of a dietary phospholipid supplementation 15 healthy female subjects received over 10 days daily 3 g of milk phospholipids stirred in a dairy product. During the following 10 days the subjects were supplemented with daily 6 g milk phospholipid. Finally, the subjects received over 10 days 6 g of the milk phospholipid in a dairy product and 2 g of plant sterols serving a commercial product.

Study Timeline

• Study Start: 2010-05
• Primary Completion: 2010-06
• Study Completion: 2010-06
• Status Verified: 2011-03
• Study First Submitted: 2011-03-30
• Study First Submitted QC: 2011-03-31
• Last Update Submitted: 2011-03-31
• Study First Posted: 2011-04-01
• Last Update Posted: 2011-04-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 15

Inclusion Criteria

• female
• age: between 30 and 45 years

Exclusion Criteria

• metabolic diseases
• arteriosclerosis
• pregnancy and breast feeding

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Phospholipid supplementation	Milk phospholipid	Supplementation of milk phospholipid

Primary Outcome Measures

Name	Time	Method
Change in plasma phospholipid concentration	after 0, 10, 20, and 30 days	Total phospholipid concentration; Individual phospholipid concentration (lyso phosphatidylcholine, phosphatidylcholine, sphingomyelin, phosphatidylethanolamine, phosphatidylinositol)

Secondary Outcome Measures

Name	Time	Method
Plasma lipids	after 0,10,20, and 30 days	Fatty acid fraction (total fatty acid distribution, phospholipid fatty acid distribution); Cholesterol fraction (total cholesterol, LDL cholesterol, HDL cholesterol); Triacylglycerides fraction
Fecal lipids	after 0,10,20, and 30 days	Fecal lipids (crude fat, total phospholipids, sterols, bile acids)

Trial Locations

Locations (1)

Friedrich Schiller University of Jena, Department of Nutritional Physiology; 🇩🇪 Jena, Thuringia, Germany