Cell-free Fetal DNA Concentration in Cases of Abnormal Placental Invasion .

• Conditions: Placenta Percreta; Placenta Accreta; Placenta Increta; Placenta Previa
• Interventions: Diagnostic Test: Maternal plasma cell free fetal DNA levels

• Registration Number: NCT03638024
• Lead Sponsor: Ain Shams Maternity Hospital

Brief Summary

Cell free fetal DNA might predict abnormal placental invasion

Detailed Description

This study aims to evaluate whether measurement of cell-free fetal DNA in the maternal plasma can be predictive of abnormal invasion in cases of placenta previa.

Study Timeline

• Study First Submitted: 2018-05-09
• Study First Submitted QC: 2018-08-17
• Study First Posted: 2018-08-20
• Study Start: 2018-09-01
• Status Verified: 2018-10
• Last Update Submitted: 2018-10-05
• Last Update Posted: 2018-10-09
• Primary Completion: 2019-03-03
• Study Completion: 2019-04-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Study group	Maternal plasma cell free fetal DNA levels	Maternal plasma cell free fetal DNA levels will be measured in 25 women with one or more previous cesarean section and placenta previa anterior only or with ultrasound finding suggestive of placental adhesion or invasion (accreta , increta or percreta).
Control group	Maternal plasma cell free fetal DNA levels	Maternal plasma cell free fetal DNA levels will be measured in 25 matched control with normally situated placenta without ultrasound finding suggestive of placental adhesion or invasion.

Primary Outcome Measures

Name	Time	Method
Predictive value of maternal plasma cell free DNA	4 months	Prediction of abnormal placental invasion in cases of placenta previa.; Primary aim: Is to evaluate whether measurement of cell-free fetal DNA in the maternal plasma can be predictive of abnormal placental invasion in cases of placenta previa.; Secondary aim: To decrease maternal morbidity and mortality by early prenatal diagnosis of abnormal placental invasion in placenta previa

Secondary Outcome Measures

Name	Time	Method
maternal morbidity	4 months	maternal morbidity

Trial Locations

Locations (1)

Ain Shams University, Maternity Hospital; 🇪🇬 Cairo, Egypt