Effects of Prednisolone and Pentoxifylline on the Regulation of Urea Synthesis in Alcoholic Hepatitis
Completed
- Conditions
- Alcoholic Hepatitis
- Registration Number
- NCT01245257
- Lead Sponsor
- University of Aarhus
- Brief Summary
Loss of total mass of muscles (catabolism) is a serious clinical problem in patients with alcoholic hepatitis. The liver might play an important role in this stress-catabolism by increasing the production of urea during the inflammatory process.
The purpose of this study is to examine the regulation of urea synthesis in patients with alcoholic hepatitis and to study the effect of the anti-inflammatory drugs prednisolone and pentoxifylline on this regulation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Alcoholic hepatitis (alcohol intake (> 40g/day in 6 months), bilirubin > 80 μmol/l)
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Exclusion Criteria
- Severe bacterial infections
- Other chronical inflammatory diseases
- Cancer
- Other catabolic diseases
- Treatment with prednisolone or pentoxifylline within the last 8 weeks
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Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Functional Hepatic Nitrogen Clearance At inclusion, after approximately 3 month and if severe alcoholic hepatitis also after 14 days medical treatment
- Secondary Outcome Measures
Name Time Method Clinical and biochemical measures of inflammation At inclusion, after approximately 3 month and if severe alcoholic hepatitis also after 14 days medical treatment
Trial Locations
- Locations (1)
Department of Medicine V, Aarhus University Hospital
🇩🇰Aarhus, Denmark