NCT01245257已完成不适用
Effects of Prednisolone and Pentoxifylline on the Regulation of Urea Synthesis in Alcoholic Hepatitis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Functional Hepatic Nitrogen Clearance
研究概览
简要总结
Loss of total mass of muscles (catabolism) is a serious clinical problem in patients with alcoholic hepatitis. The liver might play an important role in this stress-catabolism by increasing the production of urea during the inflammatory process.
The purpose of this study is to examine the regulation of urea synthesis in patients with alcoholic hepatitis and to study the effect of the anti-inflammatory drugs prednisolone and pentoxifylline on this regulation.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Alcoholic hepatitis (alcohol intake (> 40g/day in 6 months), bilirubin > 80 μmol/l)
排除标准
- •Severe bacterial infections
- •Other chronical inflammatory diseases
- •Other catabolic diseases
- •Treatment with prednisolone or pentoxifylline within the last 8 weeks
结局指标
主要结局
Functional Hepatic Nitrogen Clearance
时间窗: At inclusion, after approximately 3 month and if severe alcoholic hepatitis also after 14 days medical treatment
次要结局
- Clinical and biochemical measures of inflammation(At inclusion, after approximately 3 month and if severe alcoholic hepatitis also after 14 days medical treatment)
研究者
研究点 (1)
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