Efficacy and Safety of HSK21542 in Inducing Postoperative Analgesia in Undergoing Elective Laparoscopic Surgery

Phase 2

Completed

• Conditions: Analgesia
• Interventions: Drug: Placebo

• Registration Number: NCT04424251
• Lead Sponsor: Haisco Pharmaceutical Group Co., Ltd.

Brief Summary

This is a multicenter, randomized, double-blind, placebo-controlled, two-stage phase II clinical study. The main objective is to evaluate the efficacy and safety of HSK21542 injection and explore the recommended dose and administration frequency for subsequent Phase II studies in conjunction with the pharmacodynamic (PD) and pharmacokinetic (PK) characteristics.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-06-03
• Study First Submitted QC: 2020-06-07
• Study First Posted: 2020-06-09
• Study Start: 2020-07-02
• Primary Completion: 2020-12-07
• Study Completion: 2021-01-05
• Status Verified: 2024-08
• Last Update Submitted: 2024-08-21
• Last Update Posted: 2024-08-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 124

Inclusion Criteria

1. 18 ≤ age ≤ 70 years old, with no gender requirement
2. American Society of Anesthesiologists (ASA) Class I-II
3. 18 kg/m^2 ≤ BMI ≤ 40 kg/m^2
4. Subjects undergoing elective laparoscopic surgery under general anesthesia with an expected surgery duration of 1-5 h (inclusive)
5. Agree to participate in this trial and voluntarily sign the informed consent form;

Exclusion Criteria

1. History of allergy to opioids, such as urticaria, or allergic to the intraoperative anesthetics prescribed in the protocol;

2. History or evidence of any one of the following diseases prior to screening:

   1. History of cardiovascular diseases: Uncontrolled hypertension (systolic blood pressure [SBP] ≥ 170 mmHg and/or diastolic blood pressure [DBP] ≥ 105 without antihypertensive treatment, or SBP > 160 mmHg and/or DBP > 100 mmHg despite antihypertensive treatment), aneurysm, severe arrhythmia, heart failure, Adams-Stokes syndrome, New York Heart Association (NYHA) Class ≥ III, severe superior vena caval syndrome, pericardial effusion, acute myocardial ischemia, unstable angina, myocardial infarction in the last 6 months before screening, history of tachycardia/bradycardia requiring medication, and II-III degree atrioventricular block (excluding patients with pacemakers);
   2. History of respiratory disorder: Severe chronic obstructive pulmonary disease, acute exacerbation of chronic obstructive pulmonary disease, severe bronchostenosis, throat mass, history of (bronchial) tracheoesophageal fistula or airway tear, and severe respiratory tract infection in the last 2 weeks before screening;
   3. History of disorders in the nervous and psychiatric system: History of craniocerebral injury, possible convulsions, intracranial hypertension, cerebral aneurysms, and history of cerebrovascular accidents; history of schizophrenia, mania, mental aberration, long-term use of psychotropic drugs, and cognitive disorder; history of depression, anxiety, and epilepsy, etc.;
   4. Underwent major surgery within 3 months before screening and was judged by the investigator to have potential effect on the postoperative pain evaluation;

3. Any of the following airway management risks during screening:

   1. Acute asthma attacks;
   2. Sleep apnea syndrome;
   3. History or family history of malignant hyperthermia;
   4. History of failed tracheal intubation;
   5. Difficult airway (modified Mallampati score ≥ III) as determined by the investigator;

4. In receipt of any of the following drugs or therapies during the screening period:

   1. The time between randomization and the last dose of opioid or non-opioid (such as acetaminophen, aspirin [daily dose of > 100 mg], indomethacin, diclofenac, parecoxib sodium and other non-steroidal anti-inflammatory drugs) analgesics is shorter than 5 half-lives of the drug or the duration of drug efficacy (whichever is longer);
   2. Continuous use of opioid analgesics for more than 10 days for any reason within 3 months before screening;
   3. Use of drugs that affect the analgesic effect within 14 days before randomization, including but not limited to: Sedative hypnotics (benzodiazepines [triazolam, diazepam, midazolam, etc.], non-benzodiazepines [zolpidem, zopiclone, zaleplon, etc.]), sedative anesthetics (sevoflurane, anesthesia ether, nitrous oxide, thiopental, ketamine, etomidate, etc.), glucocorticoids (dexamethasone hydrochloride , methylprednisolone, etc.), anti-epilepsy drugs (carbamazepine, sodium valproate, etc.), anxiolytics (carbamazepine, diazepam, etc.), antidepressants (imipramine, amitriptyline, etc.), and Chinese herbal medicines or Chinese patent medicines with analgesic and sedative effects;
   4. Expected to receive anti-tumor drugs and treatments during the period from 14 days before randomization to the end of the follow-up period, including but not limited to chemotherapeutic drugs, targeted drugs, and Chinese herbal medicines.
   5. The time between randomization and the last use of diuretics and compound drugs containing diuretic components is shorter than 5 half-lives of the drug or the duration of drug efficacy (whichever is longer);

5. Laboratory test parameters meet one of the following criteria in the screening period and is confirmed by retests:

   1. White blood cell count < 3.0 x 10^9/L;
   2. Platelet count < 80 x 10^9/L;
   3. Hemoglobin <70 g/L;
   4. Prothrombin time > 1.5 x ULN;
   5. Activated partial thromboplastin time > 1.5 x ULN;
   6. Alanine aminotransferase and/or aspartate aminotransferase > 2 x ULN;
   7. Total bilirubin > 1.5 x ULN;
   8. Blood creatinine > 1.5 x ULN;
   9. Fasting blood glucose ≥ 11.1 mmol/L;

6. Without oxygen supplement during the screening period, the pulse oxygen saturation is < 92%;

7. During the screening period, the virological examination for hepatitis B surface antigen (HBsAg), hepatitis C antibody (HCVAb), treponema pallidum antibody, or human immunodeficiency virus (HIV) antibody is positive;

8. History of drug abuse, narcotics use and/or alcohol abuse within 3 months before screening. Alcohol abuse is defined as > 2 units of alcohol consumption per day (1 unit = 360 mL of beer containing 5% alcohol, 45 mL of liquor containing 40% alcohol, or 150 mL of wine);

9. Donated or lost ≥ 400 mL of blood within 3 months before screening;

10. Participated in any drug clinical trials within 3 months before screening (defined as the administration of the investigational product or placebo);

11. Women who are pregnant or breastfeeding; fertile women or men who are unwilling to use contraception during the trial; subjects who are planning pregnancy within 3 month after the completion of the trial (including male subjects);

12. Subjects determined by the investigator to be unsuitable for participating in this clinical study for any other reason.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Postoperative: Placebo	Placebo	Placebo；intravenous injection

Primary Outcome Measures

Name	Time	Method
Sum of Pain Intensity Differences (SPID)	Frome administration until 24 hours after administration	The time-weighted SPID at rest within 0-24 h after the first postoperative administration in each group

Secondary Outcome Measures

Name	Time	Method
The proportion of subjects with a NRS of ≤ 3	Frome administration until 24 hours after administration	The proportion of subjects in each group with a resting pain NRS of ≤ 3 at 12 h and 24 h after the first postoperative dose
Sum of Pain Intensity Differences (SPID)	Frome administration until 24 hours after administration	The time-weighted sum of pain intensity differences of the rest pain in each group within 0-12 h after the first postoperative dose
Use of remedial analgesics	Frome administration until 24 hours after administration	Cumulative dose of remedial analgesics (mg of morphine injection) in each group within 0-12 h and 0-24 h after the first postoperative dose, the percentage of subjects in each group who have not used remedial analgesics, and the time to start using remedial analgesics
Pain Intensity Differences（PID）	Frome administration until 24 hours after administration	The PID at rest at each scoring time point after the first postoperative administration in each group
Duration of analgesia	Frome administration until 24 hours after administration	The duration of analgesia after the first postoperative administration in each group
Satisfaction scores on postoperative analgesia	Frome administration until 24 hours after administration	Subject satisfaction score and investigator satisfaction score on postoperative analgesia at 24 h after the first postoperative administration in each group

Trial Locations

Locations (1)

Second Affiliated Hospital of Zhejiang University School of Medicine; 🇨🇳 Hangzhou, China