Analgesic Efficacy of Adding Dexmedetomidine to Erector Spinae Plane Block Versus Subcostal Transverse Abdominis Plane Block in Laparoscopic Cholecystectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Total dose of morphine consumption
研究概览
简要总结
Our scientific work aimed to evaluate the analgesic efficacy of dexmedetomidine as an adjuvant to erector spinae plane block versus subcostal transverse abdominis plane block in patients undergoing laparoscopic cholecystectomy.
详细描述
Laparoscopic cholecystectomy (LC) is the most commonly performed surgical procedure for the management of cholelithiasis. Acute pain after LC consists of somatic, parietal, and referred pain caused by trocar insertion, gall bladder resection, carbon dioxide insufflation, and other factors.
The subcostal transverse abdominis plane (SCTAP) block is the deposition of local anesthetic in the transverse abdominis plane inferior and parallel to the costal margin.
Ultrasound-guided erector spinae plane block (ESPB) is a popular, interfascial regional technique initially described for managing thoracic neuropathic pain.
Dexmedetomidine is an alpha-2 adrenergic receptor agonist that has been the focus of interest due to its sedative, analgesic, perioperative sympatholytic, and cardiovascular-stabilizing effects, resulting in reduced anesthetic requirements.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age from 20 to 60 years.
- •Both sexes.
- •American Society of Anesthesiologists (ASA) physical status I and II.
- •Patients were planned to undergo laparoscopic cholecystectomy.
排除标准
- •Patient's refusal to participate in the study.
- •ASA III, IV.
- •History of clinically significant cardiac, hepatic, renal, respiratory or neurological disease.
- •Coagulopathy and bleeding disorders.
- •Known allergy to any drug included in the study.
- •Systemic or local infection at the puncture site.
- •Body mass index (BMI) >35 (kg/m2).
- •Failed technique.
研究组 & 干预措施
Group I
Patients received an ultrasound-guided subcostal transverse abdominis plane block with injection of 10 ml bupivacaine 0.25 %, 5ml lignocaine 2 % plus 0.5 μg/kg dexmedetomidine in a 20 ml volume.
干预措施: Subcostal transverse abdominis plane block (Other)
Group II
Patients will receive an ultrasound-guided erector spinae plane block (ESPB) with injection of 10 ml bupivacaine 0.25%, 5 ml lignocaine 2 % plus 0.5 μg/kg dexmedetomidine in a 20 ml volume.
干预措施: Erector spinae plane block (Other)
结局指标
主要结局
Total dose of morphine consumption
时间窗: 24 hours postoperatively
If the Visual analogue scale (VAS) is ≥ 3, IV morphine was given as a bolus of 2 mg (body weight \< or = 60 kg) or 3 mg (body weight \> 60 kg) with 5 minutes' lockout interval.
次要结局
- Heart rate(24 hours postoperatively)
- Mean arterial pressure(24 hours postoperatively)
- Intraoperative opioid consumption(Intraoperatively)
- Time to first rescue analgesia(24 hours postoperatively)
- Degree of pain(24 hours postoperatively)
- Incidence of complications(24 hours postoperatively)
- Patient satisfaction(24 hours postoperatively)
研究者
Lamees Elsayed Ali Soliman Shaloof
Resident of Anesthesia, Surgical Intensive Care and Pain Therapy, Faculty of Medicine, Kafr-Elsheikh University, Kafr-Elsheikh, Egypt.
Kafrelsheikh University