Postoperative Effects of Hypochlorous Acid Versus Chlorhexidine Mouthwash Following Impacted Third Molar Extraction: A Randomized Split-Mouth Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Visual Analog Scale (VAS)
研究概览
简要总结
Impacted mandibular third molar extraction is one of the most common procedures in oral and maxillofacial surgery and is frequently associated with postoperative complications such as pain, edema, and trismus, which may negatively affect patients' quality of life. Various pharmacological and topical agents have been used to reduce these postoperative complications. Chlorhexidine gluconate mouthwash is widely considered the gold standard antiseptic agent due to its broad antimicrobial activity; however, its use may be associated with adverse effects such as tooth staining and taste alteration. Hypochlorous acid is an alternative antiseptic agent with antimicrobial and anti-inflammatory properties and good tissue compatibility.
The aim of this randomized clinical study was to compare the effectiveness of hypochlorous acid mouthwash and chlorhexidine gluconate mouthwash in reducing postoperative complications following impacted mandibular third molar surgery. A total of 43 healthy patients with bilateral impacted mandibular third molars were included in the study. Postoperative outcomes including pain (VAS), edema, trismus, and wound healing were evaluated at specific follow-up intervals. The results were analyzed to determine whether hypochlorous acid could be considered a potential alternative to chlorhexidine in postoperative oral care.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 18 and 40 years
- •Presence of bilateral impacted mandibular third molars with similar surgical difficulty
- •Good general health with no systemic disease
- •Ability to comply with postoperative instructions and follow-up visits
排除标准
- •Presence of systemic disease
- •Pregnancy or breastfeeding
- •Active infection at the surgical site
- •History of allergy to study medications
- •Use of antibiotics or anti-inflammatory drugs within two weeks before surgery
- •Temporomandibular joint disorders causing limited mouth opening
研究组 & 干预措施
chlorhexidine gluconate
Patients used chlorhexidine gluconate mouthwash starting 24 hours after surgery, three times daily.
干预措施: Hypochlorous Acid (Drug)
chlorhexidine gluconate
Patients used chlorhexidine gluconate mouthwash starting 24 hours after surgery, three times daily.
干预措施: Chlorhexidine Gluconate Mouthwash (Drug)
Hypochlorous Acid Mouthwash
Patients used hypochlorous acid mouthwash starting 24 hours after surgery, three times daily.
干预措施: Hypochlorous Acid (Drug)
Hypochlorous Acid Mouthwash
Patients used hypochlorous acid mouthwash starting 24 hours after surgery, three times daily.
干预措施: Chlorhexidine Gluconate Mouthwash (Drug)
结局指标
主要结局
Visual Analog Scale (VAS)
时间窗: 3, 6, 12 and 24 hours and the 2nd, 3rd, 4th, 5th, 6th and 7th days
n the pain assessment, the patients were given a VAS form at 3, 6, 12 and 24 hours and on the 2nd, 3rd, 4th, 5th, 6th and 7th days and the pain felt by the patient was marked on this scale. This form consists of numbers between 0 and 10. 0 represents 'no pain at all' and 10 represents 'worst possible pain'.
Trismus
时间窗: preop, 2th and 7th days
In all patients participating in the study, the maximum interincisal distance for trismus was measured and recorded by the same physician before the operation and on the 2nd and 7th days after the operation.
Edema
时间窗: preop, 2th and 7th days
For edema, some anatomical points on the face were taken as reference points and the distance between these points was measured with a tape measure and recorded. The angulus point was determined as the center point and the distances between angulus-tragus, angulus-lateral corner of the eye, angulus-nasal base, angulus-labial commissure and angulus-pogonion point were measured.
次要结局
未报告次要终点
研究者
Serap Keskin Tunc
Associate Professor
Yuzuncu Yil University