NCT01121003CompletedNot Applicable
Effects of a Weight Maintenance, High Fructose Diet and of Exercise on Hepatic Lipid Metabolism
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Lausanne
- Enrollment
- 8
- Locations
- 1
- Primary Endpoint
- Hepatic de novo lipogenesis
Study Overview
Brief Summary
8 healthy male volunteers will be studied each on 3 occasions, ie
- after 4 days on a weight maintenance diet containing 5% simple sugars + low physical activity
- after 4 days on a weight maintenance diet containing 30% fructose + low physical activity
- after 4 days on a weight maintenance diet containing 30% fructose + high physical activity At the end of each of these 3 periods, fructose induced hepatic de novo lipogenesis (13C palmitate synthesis in response to ingestion of a 13C fructose load) and plasma VLDL-triglyceride kinetics (measured with a bolus of 2H-labeled glycerol) will be measured
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 30 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •age between 18 and 30 years
- •BMI between 19 and 25
- •low to moderate physical activity (< 3 sessions/week)
Exclusion Criteria
- •consumption of alcohol>50g/week
- •consumption of drugs or illicit substances
- •food allergies
Arms & Interventions
Low fructose diet/no exercise
Other
Intervention: weight maintenance, low sugar diet (Behavioral)
high fructose diet/no exercise
Experimental
Intervention: weight maintenance, high fructose diet (Behavioral)
high fructose diet+exercise
Experimental
Intervention: weight maintenance, high fructose diet+ exercise (Behavioral)
Outcomes
Primary Outcomes
Hepatic de novo lipogenesis
Time Frame: after 4 days on controlled diet+exercise
Measurement of 13C VLDL palmitate after ingestion of 13C fructose
Secondary Outcomes
- Plasma VLDL-triglyceride kinetics(after 4 days on controlled diet+exercise)
Investigators
Luc Tappy, MD
Professor of Physiology
University of Lausanne
Study Sites (1)
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