Effect of Hyaluronic-acid on the Healing After Free Gingival Graft

Phase 2

Completed

• Conditions: Gingival Recession
• Interventions: Biological: Hyaluronic acid group

• Registration Number: NCT03871218
• Lead Sponsor: Gazi University

Brief Summary

This study evaluated the effect of topical hyaluronic acid (HA) application on free gingival graft (FGG) donor and recipient sites during the early wound healing period with laser Doppler flowmetry (LDF) and to investigate the effect of HA application on the dimensional change of the graft.Participants were randomly classified into the test group (TG) and control group (CG). HA was applied to both donor and recipient sites in 20 patients who formed the TG, whereas HA was not applied to the 20 patients who formed the CG.

Detailed Description

The healing of a transplanted tissue depends on the formation of blood support between the donor and recipient sites.

Hyaluronic acid (HA) is a biomaterial that creates a favorable environment for wound healing due to its unique hydroscopic and viscoelastic properties, and it is important for wound healing activities.HA induces angiogenesis following degradation and improves the wound healing environment.HA supports a mechanism that induces proliferation of capillaries, and components produced after HA degradation increase vascularization.Laser Doppler flowmetry (LDF) technique is frequently used in the field of plastic surgery for monitoring microvascular blood flow to detect insufficient circulation in the skin transplants and flaps in the early period and to thereby prevent and predict possible surgical complications.

Study Timeline

• Status Verified: 2017-04
• Study Start: 2017-04-01
• Primary Completion: 2018-04-01
• Study Completion: 2018-12-01
• Study First Submitted: 2019-03-10
• Study First Submitted QC: 2019-03-10
• Study First Posted: 2019-03-12
• Last Update Submitted: 2019-07-29
• Last Update Posted: 2019-07-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Clinically diagnosed inadequate attached gingiva

Exclusion Criteria

• Smoking

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Test Group	Hyaluronic acid group	Hyaluronic acid application group. After FGG was taken from the donor region in the TG, sterile gauze was applied with moderate pressure for 2 minutes, and HA was applied topically after the bleeding stopped. The cross-linked HA package containing 20 mg/ml Na-hyaluronate, stored at room temperature, was opened, and the protective cap of the syringe was removed.

Primary Outcome Measures

Name	Time	Method
blood perfusion value in the recipient bed	on day 4	The comparison of blood perfusion value in the recipient bed between the TG and CG on day 4

Trial Locations

Locations (1)

Gazi University Faculty of Dentistry Department of Periodontology; 🇹🇷 Ankara, Çankaya, Turkey