Evaluation of Dysfunction of the Basal Ganglia Before a Parkinsonian Walking in the Elderly: Risk of Falling and Confusional State

Completed

• Conditions: the Elderly

• Registration Number: NCT02885493
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

The strong relationship between falling and severity of cognitive impairment in the elderly is well established. The association premorbid gait and executive disorders suggests that they are under tension by the same mechanisms. The gait fortiori neurological are fall risk factors. Dysfunctions underlying disorders as Parkinson called march executive disorders are subcortical origin involving so the basal ganglia. This study is indeed based on the assumption that the dysfunction of the basal ganglia as observed in parkinsonian syndromes resulting in disorders of posture and walking, by dysexecutive syndrome, anxiety and the contrast vision disorders. These gait exposed to falls and dysexecutive these disorders with cognitive impairment and greater susceptibility to confusional states. The executive disorders, gait disorders, anxiety, disturbances of vision and especially saccadic eye movements, impaired vision contrasts are well established in the degenerative parkinsonian syndromes. This study proposes a new approach to assessing gait disorders to define a high risk of falling in the presence of parkinsonian walking in the elderly over 75 years.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-03-20
• Study First Submitted: 2016-08-26
• Study First Submitted QC: 2016-08-26
• Study First Posted: 2016-08-31
• Status Verified: 2019-09
• Primary Completion: 2019-09
• Study Completion: 2019-09
• Last Update Submitted: 2019-09-17
• Last Update Posted: 2019-09-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Age: 75 years,
• man or woman,
• Diagnostic Criteria for Parkinson walking: at least 3 of the following symptoms:
• Loss of swinging arms,
• Decrease in stride walking slowly,
• feet as glued to the ground,
• Trample,
• piece U-turn,
• kyphotic Attitude,
• Tolerance screw physiotherapy screws

Exclusion Criteria

• Unrecovered delirium,

• Unable to walk for a distance of 6 meters in length without technical assistance,

• Traumatic fall phase of rehabilitation,

• Acute pathology,

• Unstabilized psychiatric pathology,

• Symptomatic orthostatic hypotension,

• Severe depressive syndrome untreated

• Subjects with a sufficient gap to explain the falls:

  • cerebellar syndrome,
  • a pyramidal syndrome with sequelae pyramidal deficit and cortical stroke
  • peripheral pathology,
  • rheumatic disease,
  • orthopedic pathology,

• Mini Metam State Examination <18,

• Parkinsonism induced by neuroleptics,

• Not cured cancer,

• Psychotropic drugs (benzodiazepines and antipsychotics) with significant sedative effect inducing excessive daytime sleepiness namely psychotropic half long life, and high dose over 2 psychotropic

• Severe heart failure

• Severe respiratory failure,

• Associated diseases and treatments interfering

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
falls risks	number of falls during follow-up of 24 months	Assess Falls development risk in the presence of parkinsonian walking

Secondary Outcome Measures

Name	Time	Method
number of confusional states	follow-up of 24 months
number of hospitalizations	follow-up of 24 months
mortality	follow-up of 24 months

Trial Locations

Locations (1)

Hôpitaux Universitaires de Strasbourg; 🇫🇷 Strasbourg, France