An Extension Study of Lirentelimab in Eosinophilic Gastritis and/or Eosinophilic Duodenitis (Formerly Referred to as Eosinophilic Gastroenteritis)
- Conditions
- Eosinophilic DuodenitisEosinophilic Gastritis
- Interventions
- Registration Number
- NCT04620811
- Lead Sponsor
- Allakos Inc.
- Brief Summary
This is a Phase 3, open-label, extension study to assess the long term efficacy and safety of lirentelimab given monthly.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 159
- Provide written informed consent.
- Completed Study AK002-016, defined as having received 6 infusions of study drug and followed through Day 176 (±3) or completed Study AK002-012, defined as having received the cohort-appropriate amount of doses and followed for 5 months after last dose of study drug.
- If patient is on pre-existing dietary restrictions, willingness to maintain those restrictions, throughout the study.
- Able and willing to comply with all study procedures.
- Female patients must be either post-menopausal for at least 1 year or surgically sterile (tubal ligation, hysterectomy, or bilateral oophorectomy) for at least 3 months, or if of childbearing potential, have a negative pregnancy test and agree to use dual methods of contraception, or abstain from sexual activity until the end of the study, or for 120 days following the last dose of study drug, whichever is longer.
- Male patients with female partners of childbearing potential must agree to use a highly effective method of contraception until the end of the study or for 120 days following the last dose of study drug, whichever is longer. All fertile men with female partners of childbearing potential should be instructed to contact the Investigator immediately if they suspect their partner might be pregnant at any time during study participation.
Key
- Known hypersensitivity to any constituent of the study drug.
- Any disease, condition (medical or surgical), or cardiac abnormality, which, in the opinion of the Investigator, would place the patient at increased risk.
- Planned or expected vaccination with live attenuated vaccines during the Treatment Period, or vaccination expected within 5 half-lives (4 months) of AK002 administration.
- Women who are pregnant, breastfeeding, or planning to become pregnant while participating in the study.
- Any other reason that, in the opinion of the Investigator or Medical Monitor, makes the patient unsuitable for enrollment.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 3.0 mg/kg of Lirentelimab (AK002) lirentelimab Subjects in this arm will receive up to 18 monthly doses (3mg/kg) of lirentelimab (AK002)
- Primary Outcome Measures
Name Time Method The Safety and Tolerability of Lirentelimab by Evaluating Adverse Events Assessed Using the CTCAE Version 5.0 Through study completion, up to 21 months Adverse events assessed using the CTCAE version 5.0.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (38)
Allakos Investigational Site 216-038
🇺🇸Tustin, California, United States
Allakos Investigational Site 216-051
🇺🇸Boston, Massachusetts, United States
Allakos Investigational Site 216-045
🇺🇸Reno, Nevada, United States
Allakos Investigational Site 216-021
🇺🇸Philadelphia, Pennsylvania, United States
Allakos Investigational Site 216-028
🇺🇸Cincinnati, Ohio, United States
Allakos Investigational Site 216-002
🇺🇸Huntsville, Alabama, United States
Allakos Investigational Site 216-032
🇺🇸Chula Vista, California, United States
Allakos Investigational Site 216-014
🇺🇸Santa Monica, California, United States
Allakos Investigational Site 216-049
🇺🇸Walnut Creek, California, United States
Allakos Investigational Site 216-063
🇺🇸Brandon, Florida, United States
Allakos Investigational Site 216-027
🇺🇸Edgewater, Florida, United States
Allakos Investigational Site 216-056
🇺🇸Jacksonville, Florida, United States
Allakos Investigational Site 216-013
🇺🇸Miami, Florida, United States
Allakos Investigational Site 216-053
🇺🇸New Port Richey, Florida, United States
Allakos Investigational Site 216-007
🇺🇸Chicago, Illinois, United States
Allakos Investigational Site 216-026
🇺🇸Boston, Massachusetts, United States
Allakos Investigational Site 216-001
🇺🇸Crowley, Louisiana, United States
Allakos Investigational Site 216-052
🇺🇸Boston, Massachusetts, United States
Allakos Investigational Site 216-042
🇺🇸Kansas City, Missouri, United States
Allakos Investigational Site 216-025
🇺🇸New York, New York, United States
Allakos Investigational Site 216-020
🇺🇸Chapel Hill, North Carolina, United States
Allakos Investigational Site 216-050
🇺🇸Winston-Salem, North Carolina, United States
Allakos Investigational Site 216-031
🇺🇸Cincinnati, Ohio, United States
Allakos Investigational Site 216-044
🇺🇸Mentor, Ohio, United States
Allakos Investigational Site 216-003
🇺🇸Chattanooga, Tennessee, United States
Allakos Investigational Site 216-006
🇺🇸Chattanooga, Tennessee, United States
Allakos Investigational Site 216-022
🇺🇸Austin, Texas, United States
Allakos Investigational Site 216-039
🇺🇸Ogden, Utah, United States
Allakos Investigational Site 216-055
🇺🇸Sandy, Utah, United States
Allakos Investigational Site 216-064
🇺🇸Spokane, Washington, United States
Allakos Investigational Site 216-011
🇺🇸Chattanooga, Tennessee, United States
Allakos Investigational Site 216-062
🇺🇸Kingsport, Tennessee, United States
Allakos Investigational Site 216-035
🇺🇸Phoenix, Arizona, United States
Allakos Investigational Site 216-048
🇺🇸Durham, North Carolina, United States
Allakos Investigational Site 216-030
🇺🇸Salt Lake City, Utah, United States
Allakos Investigational Site 216-068
🇺🇸Birmingham, Alabama, United States
Allakos Investigational Site 216-034
🇺🇸Aurora, Colorado, United States
Allakos Investigational Site 216-005
🇺🇸Rochester, Minnesota, United States