The microcirculation in the pathogenesis of organ failure in patients with acute heart failure.

Recruiting

• Conditions: Cardiogenic shock; severe heart failure; 10019280

• Registration Number: NL-OMON30972
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 100

Inclusion Criteria

1. Age of 18 years or older.
2. Admitted with the diagnosis acute heart failure (criteria: see protocol).

Exclusion Criteria

1. Pregnancy (results in an altered hemodynamic state).
2. Oral bleeding.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Microvascular flow index, as obtained by SDF imaging.<br /><br>2. Daily SOFA scores, as a measure for (multiple) organ failure.<br /><br>3. Survival.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Data collection:<br /><br><br /><br>1. Clinical: Gender, age, length, weight, body temperature, Glascow Coma Scale,<br /><br>APACHE IV score, SAPS II score, diuresis.<br /><br>2. (Macro)Hemodynamics: Heart rate, arterial blood pressure, central venous<br /><br>pressure, cardiac output, pulmonary artery pressure, pulmonary wedge pressure.<br /><br>3. Respiratory: Positive end expiratory pressure (PEEP), respiratory rate.<br /><br>4. Laboratory: Arterial blood gas analysis (pH, PaCO2, PaO2, SaO2), central<br /><br>venous blood gas analysis (ScvO2, PvCO2), lactate, glucose, hemoglobin (Hb),<br /><br>hematocrit (Ht), urea, creatinin, thrombocytes, leukocyrtes, PT/APTT/ACT.<br /><br>5. Oxygen delivery: DO2=CO*13.4*[Hb]*SaO2.<br /><br>6. Oxygen uptake: VO2=CO*13.4*Hb*(SaO2-SvO2).</p><br>