Effect of Isometric Handgrip Training on Cardiovascular Risk in Hypertensives
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 72
- Locations
- 1
- Primary Endpoint
- Change in office blood pressure
Study Overview
Brief Summary
The main purpose this study is to analyze the effects of isometric handgrip training on cardiovascular risk in hypertensive. For this, approximately 60 hypertensive, under anti-hypertensive medication, will be selected and randomly distributed into three groups: home-based isometric handgrip training (HBT), supervised isometric handgrip training (ST) and control group (CG).Subjects assigned to the HBT and ST will train three times per week for a total of 12 weeks, will perform a bout of isometric handgrip exercise: four sets of 2-min isometric contractions (using alternate hands) at 30% of maximal voluntary contraction. However, the subjects of the HBT group conduct the training without daily supervision. Subjects randomized to the CG will be encouraged to increase the level of physical activity and make healthy eating, without, however, receive specific recommendations.Baseline and after 12 weeks of intervention, the following cardiovascular risk indicators will be obtained: blood pressure, arterial stiffness, cardiac autonomic modulation, vasodilatory capacity and oxidative and inflammatory stress markers, in addition to microalbuminuria. For data analysis, in addition to descriptive statistics, two-way ANOVA for mixed model will be applied for within and between groups comparison. If the premises of this test are met. The level of significance that will be adopted is p<0.05.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Investigator, Outcomes Assessor)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Clinical diagnosis of hypertension;
- •Must be under anti-hypertensive medications of three months or more;
- •May not present diabetes or other cardiovascular diseases;
- •May not engaged in regular physical activity;
- •May not have disabilities that compromise the physical activity practices.
Exclusion Criteria
- •Not perform more than 85% of the training sessions;
- •Present diagnosis of metabolic diseases, cardiovascular or pulmonary during the study;
- •Adherence to other physical activity program beyond the training offered by this study;
- •Change in class and / or dose of medication during the study;
- •Not using the medication regularly;
- •Worsening of the disease.
Arms & Interventions
Home-based isometric handgrip training
All participants that will be assigned to home-based isometric handgrip training (HBT) will train three times per week for a total of 12 weeks, will perform a bout of isometric handgrip exercise: four sets of 2-min isometric contractions (using alternate hands) at 30% of maximal voluntary contraction; however, the training will be performed without daily supervision. Therefore, the subjects will receive a logbook to record the exercise sessions. In addition, visits will be scheduled at weeks 1, 3, 6, 9 and 11 to provide feedback to individuals and discuss potential problems in conducting training.
Intervention: Isometric handgrip training (Other)
Supervised isometric handgrip training
All participants that will be assigned to supervised isometric handgrip training (ST) will train three times per week for a total of 12 weeks, will perform a bout of isometric handgrip exercise: four sets of 2-min isometric contractions (using alternate hands) at 30% of maximal voluntary contraction with. The training will be performed with daily supervision.
Intervention: Isometric handgrip training (Other)
Control group
Subjects randomized to the control group (CG) will be encouraged to increase the level of physical activity and make healthy eating, without, however, receive specific recommendations
Outcomes
Primary Outcomes
Change in office blood pressure
Time Frame: Baseline and 12 weeks
Secondary Outcomes
- Change in ambulatory blood pressure(Basaline and 12 weeks)
- Change in central blood pressure(Basaline and 12 weeks)
- Change in cardiac autonomic modulation(Baseline and 12 weeks)
- Change in vasodilatory capacity(Baseline and 12 weeks)
- Change in arterial stiffness(Baseline and 12 weeks)
- Change in markers of oxidative stress(Baseline and 12 weeks)
- Change in markers of inflammation(Baseline and 12 weeks)
Investigators
Breno Quintella Farah
PhD student
University of Pernambuco