The Mediating Effect of Nociplastic Pain on the Relationship Between Rheumatoid Arthritis Severity and Cognition in Geriatric Patients: A Cross-Sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- RA disease severity as measured by the Physician Global Assessment (0-10 VAS)
研究概览
简要总结
this study aims to determine if nociplastic pain mediates the relationship between rheumatoid arthritis (RA) severity and cognitive impairment in geriatric patients 100 patients aged 65-90 years with long-standing RA and assess their disease severity, cognition, and pain sensitization will be recruited. Expectations that patients with more severe RA will have worse cognitive function, and that this relationship will be mediated by higher levels of nociplastic pain.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 65 Years 至 90 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 65-90 years
- •diagnosed with RA for 10-30 years
- •meet ACR/EULAR 2010 criteria
排除标准
- •Other inflammatory arthritides
- •severe depression
- •recent corticosteroid or immunosuppressant use
结局指标
主要结局
RA disease severity as measured by the Physician Global Assessment (0-10 VAS)
时间窗: Baseline
Description: 0 = no disease activity; 10 = maximum disease activity
Cognitive function as measured by the Montreal Cognitive Assessment (MoCA)
时间窗: Baseline
The MoCA assessments cognition in multiple domains; scores ≤26 indicate cognitive impairment. The MoCA is scored out of 30 points, with a higher score indicating better cognitive function. The maximum score on the MoCA is 30, while the minimum score is 0. The test typically takes around 10-15 minutes to complete and is administered by a trained healthcare professional.
Centralized pain as measured by the Central Sensitization Inventory (CSI)
时间窗: Baseline
The CSI determines the degree of pain centralization/sensitization. The CSI consists of 25 items that assess various symptoms and experiences associated with CSS, including pain severity and quality, sleep disturbances, fatigue, mood changes, and cognitive difficulties. The CSI is scored on a 0-100 scale, with higher scores indicating a greater degree of central sensitization. A score of 40 or higher is generally considered to indicate the presence of CSS, while a score of 60 or higher indicates a high degree of central sensitization.
次要结局
- Patient Global Assessment (0-10 VAS)(Baseline)
- Inflammatory markers (ESR)(Baseline)
- Inflammatory markers (CRP)(Baseline)
- 28-joint swollen/tender joint count(Baseline)
研究者
Mohamed Magdy ElMeligie
Lecturer of Physical Therapy and Director of Electromyography Lab
Ahram Canadian University