Antituberculosis treatment in incomplete transverse myelitis in steroid-refractory patients: a prospective open label study

Sun Yat-sen University (China)0 个研究点目标入组 67 人开始时间: 2010年4月9日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•1. Development of sensory, motor, or autonomic dysfunction attributable to the spinal cord
•2. Varying degrees of motor, sensory and sphincter dysfunction (though not necessarily symmetrical), but without complete paraplegia
•3. Exclusion of extra-axial compressive aetiology by magnetic resonance imaging (MRI)
•4. Worsened condition despite at least one 5-day course of intravenous (IV) methylprednisolone (0.5 - 1 g/d)
•5. Cerebrospinal fluid mycobacterium tuberculosis (CSF MTB) culture were negative, with cell count less than 50/mm^3 and total protein less than 1.5 g/L
•6. Aged 18 - 70 years, either sex

•1. Sudden onset
•2. History of previous radiation to the spine within the last 10 years
•3. Central nervous system (CNS) manifestations of syphilis, Lyme disease, human immunodeficiency virus (HIV) infection
•4. Clear arterial distribution clinical deficit consistent with thrombosis of the anterior spinal artery
•5. History of clinically apparent optic neuritis
•6. Brain MRI abnormalities suggestive of multiple sclerosis (MS) and clinically definite MS
•7. Serologic or clinical evidence of connective tissue disease (sarcoidosis, Behcet's disease, Sjögren's syndrome, systematic lupus erythematosis [SLE], mixed connective tissue disorder, etc)

发起方

Sun Yat-sen University (China)